Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats

Abstract

Background Diabetes mellitus is one of the most common todays public health problems. According to a survey by the World Health Organization, this metabolic disorder has reached global epidemic proportions, with a worldwide prevalence of 8.5% in the adult population. Objectives The present study aimed to investigate the hypoglycemic effect of aqueous extract of Mangifera indica (EAMI) leaves in streptozotocin-induced diabetic rats. Methods Sixty male rats were divided into 2 groups: Normoglycemic and Diabetic. Each group was subdivided into negative control, glibenclamide 3 or 10 mg/kg, EAMI 125, 250, 500, and 1000 mg/kg. Intraperitoneal injection of streptozotocin 100 mg/kg was used to DM induction. The hypoglycemic response was assessed acutely after two and four weeks of treatment. After a 6-hour fasting period, the fasting blood glucose of animals was verified, and 2.5 g/kg glucose solution was orally administered. The insulin tolerance test and plasma insulin levels assessment were performed in the morning after fasting of 12 to 14 hours.

Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate

“…It can also absorb glucose in the intestines, which in turn can prevent its systematic absorption. 18 Decreased glucose levels in rats can be caused by the mechanism of action of mango leaf extract by inhibiting α-amylase (reducing postprandial hyperglycemia and also preventing the development of diabetes), reducing glucose absorption (reducing glucose through the intestinal lumen, can reduce postprandial hyperglycemia), eliminating free radicals will induce cell damage, in the presence of antioxidants from mango leaves free radicals will be neutralized, so that it will protect cells from the toxic effects of free radicals, can also prevent pathogenesis and complications of diabetes mellitus), inhibitors of Nitric Oxide production (high levels of NO can produce free radicals). peroxynitrite which can harm cells, will later bind to proteins and affect).…”

Antidiabetic Effects of Medicinal Plants

“…Exhibited dose-dependent inhibition against αglucosidase activities [109,110] and α-amylase [110]. Decreased blood glucose level beyond glibenclamide effects with increase in the sensitivity of insulin and plasma insulin levels [111]. Prevented the decline in body weight and decrease in β-cell mass [112].…”

Nelsonia canescens (Acanthaceae) aqueous extract and partitioned fractions ameliorates type-2 diabetes in alloxan-induced diabetic rats

“…The modern oral hypoglycemic drugs produce undesirable and adverse side effects [2]. Therefore, alternative therapy with improved therapeutic potentials and less side effects is urgently needed [15]. There are many traditional herbal medicines recommended for the treatment and management of diabetes [15].…”

“…Therefore, alternative therapy with improved therapeutic potentials and less side effects is urgently needed [15]. There are many traditional herbal medicines recommended for the treatment and management of diabetes [15]. About 25% of the drugs prescribed across the world are derive from plants already used in traditional medicine [15].…”

“…There are many traditional herbal medicines recommended for the treatment and management of diabetes [15]. About 25% of the drugs prescribed across the world are derive from plants already used in traditional medicine [15]. Herbal drugs are prescribed widely because of their effectiveness, less side effects and relatively low cost [11][12][13]16].…”