Acute Toxicity Tests of Metrizamide

Monomeric ionic contrast media are known to induce a significant degree of pulmonary edema following intravenous injection of high doses of contrast media in rats. This edema has been shown to be dependent on dose and rate of injection. Metrizamide administered at the same dose causes much less and more transient pulmonary edema than diatrizoate. Although blood osmolalities were significantly and consistently lower following administration of metrizamide compared with diatrizoate, this difference alone does not account for the difference in the degree of pulmonary edema induced by these media.

Section: Discussionmentioning

confidence: 99%

Pulmonary Edema Induced by Contrast Medium

Måre¹,

Violante²

1983

“…At an injection rate of 1.2 ml/min (300 mg I/ml) the intravenous LD 50 in mice is 18.6 g I/kg for met rizamide and 21.9 g I/kg for C29 (SALVESEN 1977). Thus, C29 has a low acute intravenous toxicity.…”

Section: Metrizamide (mentioning

confidence: 97%

“…

Metrizamide ( Figure), which was the first nonionic water-soluble contrast medium on the market, has a lower subarachnoid and intravenous toxicity than presently available ionic monomeric media (SALVESEN 1973). Metrizamide does not tolerate autoclaving and is therefore sterilized by filtration and then freeze-dried.

…”

mentioning

confidence: 99%

Liver Toxicity of Diatrizoate and a Non-Ionic Contrast Medium (C29)

Måre¹,

Almén²,

Waldenström³

1980

“…This peak could Results nografin 60 (Squibb), containing 520 mg diatrizoate meglumine and 80 mg diatrizoate sodium per ml providing 290 mg IIml, was injected. The LD 50 value of this commonly used medium is about 8 g IIkg in the rat (SALVESEN 1973) and the osmolality is 1420 mmol/kg.…”

Section: Minutes Post Injectionmentioning

confidence: 99%

Pulmonary Edema Induced by High Intravenous Doses of Diatrizoate in the Rat

Måre¹,

Violante²

1983

Using a simple, sensitive model, it has been demonstrated that intravenous administration of high doses of contrast medium can induce pulmonary edema in non-anesthetized rats. The degree of edema formation, which is dependent on the rate of injection as well as dose, is greatest immediately after injection and then decreases slowly. The amount of fluid accumulation in the lungs is related to the chemotoxicity of the medium as other solutions of equivalent hyperosmolality did not induce the same degree of pulmonary edema.