Liver Toxicity of Diatrizoate and a Non-Ionic Contrast Medium (C29)

Måre, Klas; Almén, Torsten; Waldenström, J

doi:10.1177/028418518002100519

Acta Radiologica. Diagnosis

1980

DOI: 10.1177/028418518002100519

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Liver Toxicity of Diatrizoate and a Non-Ionic Contrast Medium (C29)

Klas Måre¹,

Torsten Almén²,

J Waldenström³

Abstract: Toxic effect on the liver of diatrizoate and a new non-ionic contrast medium (C29) were investigated using coeliac angiography in rabbits. The contrast media were injected in doses of 5 ml/kg rabbit with a concentration of 370 mg I/ml. Serum levels of ALAT, ASAT, ALP and bilirubin did not change significantly after the injections.

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1984

1987

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Cited by 2 publications

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Effect of Ioxaglate on the Liver and Pancreas following Selective Visceral Angiography in Man

Nilsson¹,

Jönsson²

1984

Acta Radiologica. Diagnosis

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Selective visceral angiography was performed with the ionic, monoacidic, dimeric contrast medium ioxaglate (280 and 320 mg I/ml). Twenty patients with and without disease of the liver and/or pancreas were prospectively and consecutively studied. Changes in the serum activities of ALAT, ASAT, GT, AP, and pancreatic isoamylase and changes in the level of serum bilirubin, prothrombin index and haematocrit were evaluated sequentially before and after angiography. The total volume of contrast medium ranged from 100 to 340 ml per patient and the median dosage was 3.5 ml per kg body weight. There was no statistically significant elevation within the entire group of patients in the measured parameters after angiography when compared with pre-angiographic values. No clinically important toxic effect on the liver or pancreas induced by the contrast medium was found.

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Effect of Ioxaglate on the Liver and Pancreas following Selective Visceral Angiography in Man

Nilsson¹,

Jönsson²

1984

Acta Radiologica. Diagnosis

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Effects of Metrizoate and Iohexol on the Liver at Visceral Angiography

1987

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Hepatic angiography was performed in a double-blind two-group study in 60 patients using iohexol 350 mg I/ml and ***metrizoate 350 mg I/ml. A slight increase in serum values of hepatic enzymes was found when metrizoate was used, particularly in patients with impaired liver function. Iohexol gave considerably less pain and sensation of heat than did metrizoate. A non-expected significant increase of creatine kinase was recorded when iohexol was used. The reason for this is not yet known.

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Liver Toxicity of Diatrizoate and a Non-Ionic Contrast Medium (C29)

Cited by 2 publications

References 3 publications

Effect of Ioxaglate on the Liver and Pancreas following Selective Visceral Angiography in Man

Effect of Ioxaglate on the Liver and Pancreas following Selective Visceral Angiography in Man

Effects of Metrizoate and Iohexol on the Liver at Visceral Angiography

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