1987
DOI: 10.1177/028418518702800609
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Effects of Metrizoate and Iohexol on the Liver at Visceral Angiography

Abstract: Hepatic angiography was performed in a double-blind two-group study in 60 patients using iohexol 350 mg I/ml and ***metrizoate 350 mg I/ml. A slight increase in serum values of hepatic enzymes was found when metrizoate was used, particularly in patients with impaired liver function. Iohexol gave considerably less pain and sensation of heat than did metrizoate. A non-expected significant increase of creatine kinase was recorded when iohexol was used. The reason for this is not yet known.

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“…Further, only small and transient changes of hepatic enzyme levels following hepatic angiography with iohexol were found in pigs (Jensen et al., 1980 ). Comparative clinical trials have been performed on various radiologic indications, where iohexol has been compared with conventional ionic contrast media show that there was no significant increase in serum values of hepatic or pancreatic enzymes nor of electrolytes following either of the two contrast media (Billström et al., 1987 ).…”
Section: Discussionmentioning
confidence: 99%
“…Further, only small and transient changes of hepatic enzyme levels following hepatic angiography with iohexol were found in pigs (Jensen et al., 1980 ). Comparative clinical trials have been performed on various radiologic indications, where iohexol has been compared with conventional ionic contrast media show that there was no significant increase in serum values of hepatic or pancreatic enzymes nor of electrolytes following either of the two contrast media (Billström et al., 1987 ).…”
Section: Discussionmentioning
confidence: 99%