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The results obtained with metrizamide in the screening test with suboccipital injection to mice (SALVESEN 1973) encouraged to further experiments. A survey of the literature dealing with subarachnoid injections of water-soluble contrast media to animals shows that most of the experiments have been carried out for histologic examinations of the nervous tissue or meninges. However, a few investigations have been done with recordings of physiologic parameters. Thus, FUNKQUIST & OBEL (1960) recorded EMG, arterial blood pressure and pulse rate after lumbar subarachnoid injections of methiodal sodium to dogs. More recently, MELARTIN (1970) made a comparison of the effect of meglumine iothalamate and meglumine diatrizoate on arterial blood pressure, spinal fluid pressure and respiration after suboccipital injections to dogs. The results of these two reports show that marked changes occurred in the arterial blood pres sure, the spinal fluid pressure and the EMG.We intended to compare the effect of large subarachnoid doses of metrizamide and meglumine iocarmate which recently has been introduced as a myelographic contrast medium and is at present considered to be the best water-soluble medium for this purpose.Suboccipital injections to anaesthetized rabbits revealed that metrizamide was tolerated in much larger doses than meglumine iocarmate. It was therefore decided not to use equal dose levels of the two media in the experiments. The 93

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