Pulmonary Edema Induced by High Intravenous Doses of Diatrizoate in the Rat

Måre, Klas; Violante, Michael R.

doi:10.1177/028418518302400512

Cited by 14 publications

(2 citation statements)

References 40 publications

(6 reference statements)

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“…The dose of contrast media and rate of injection: intravenous administration of high doses of contrast media induced pulmonary edema in nonanesthetized rats (Mare and Violante, 1983a, 1983b). The degree of edema formation was dependent on the rate of contrast media injection as well as dose.…”

Section: Endothelial Damagementioning

confidence: 99%

Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Ramot

Nyska²

2007

Toxicol Pathol

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Awareness of the dangers of drug-induced thrombosis has recently been heightened and led to demand for improved testing methodology. For example, reports indicating that some selective inhibitors of cyclooxygenase-2 (COX-2) increase the risk of myocardial infarction and atherothrombotic events caused the withdrawal of rofecoxib from global markets and the issuance of warnings concerning the usage of other COX-2 inhibitors. Drugs may exert a prothrombotic state by a variety of mechanisms-those affecting the vessel wall, the blood flow, and/or different blood constituents. Our review serves as an update to that of Gerhard Zbinden published in 1976 by presenting recently acquired data that more fully elucidate the different mechanisms by which drugs are believed to induce thrombogenic effects and discussing new methods used to detect these without losing sight of the classical pathology of thrombosis. We offer correlations between experimental findings and clinical data and conclude that, because drugs may induce a prothrombotic state by a variety of mechanisms, they should be tested for these using appropriate experimental methods and animal models.

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Section: Endothelial Damagementioning

confidence: 99%

Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Ramot

Nyska²

2007

Toxicol Pathol

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“…The main reason is the high osmolality of the contrast medium, which is about five to nine times higher than that of normal plasma and tissue fluid. Pulmonary edema is another complication which presumably is related to chemotoxicity of the contrast medium (24).…”

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confidence: 99%

Ioxaglate versus Diatrizoate in Selective Pulmonary Angiography

Kumazaki¹

1985

Acta Radiologica. Diagnosis

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A clinical comparison of ioxaglate and diatrizoate with regard to the cardiovascular effects following selective pulmonary angiography was performed in 20 patients with normal pulmonary arterial pressure. Ioxaglate produced a significantly less marked effect on systemic blood pressure (p less than 0.001), pulmonary arterial pressure (p less than 0.001), and heart rate (p less than 0.05-0.01), as compared with diatrizoate.

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Drug-Induced Thrombosis: An Update

2013

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Drugs may play an important role in development of thrombosis, and in recent years there has been increased attention to the importance of this issue. Although drug-induced thrombosis usually causes venous thrombotic events, arterial events are also noted due to drug administration. Here we review the different mechanisms through which drugs can exert thrombosis. Drugs can cause direct endothelial damage and expose the underlying subendothelium thus leading to platelet adherence and subsequent thrombus formation. Such an effect is seen by contrast media and chemotherapeutic cytotoxic drugs. Drugs may also attenuate the secretion of pro- and anticoagulation mediators by the endothelial cells and may have prothrombotic effects on platelets by increasing adhesion and aggregation, as for example seen after heparin administration in an immune-mediated mechanism. Red and white cells can also be affected by drugs, by increasing their aggregation or adhesion to the endothelial wall. Some drugs, such as oral contraceptive pills, may promote thrombosis by altering the balance between the different coagulation factors, and many drugs can lead to decreased blood flow by increasing blood viscosity, as seen for example after intravenous immunoglobulin administration. Better understanding of the mechanisms through which drugs exert thrombosis may facilitate their safe use in patients. Additionally, awareness of the drugs that are known to induce thrombosis is important in order to stop their administration in case of a thrombotic event. This review further emphasizes the fact that drug administration is a risk factor that should always be considered together with additional known thromboembolic risk factors such as genetic predisposition or cancer.

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Pulmonary Edema Induced by High Intravenous Doses of Diatrizoate in the Rat

Cited by 14 publications

References 40 publications

Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Ioxaglate versus Diatrizoate in Selective Pulmonary Angiography

Drug-Induced Thrombosis: An Update

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