Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Ramot, Yuval; Nyska, Abraham

doi:10.1080/01926230601156237

Cited by 40 publications

(28 citation statements)

References 119 publications

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“…Selective inhibitors of COX-2 Rofecoxib and Valdecoxib were withdrawn from market in 2007 because of increased risk of myocardial infarction and athero-thrombotic involvements. 4 Similarly, the restrictions to the use of Rosiglitazone are based on data of ADR reports which shows an elevated risk of heart attacks in patients treated with it. The decision to restrict access to Rosiglitazone was made on September 23, 2010 US-FDA.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and practice toward adverse drug reaction reporting among practicing clinicians at a tertiary care hospital

Todar

Agrawal

Hishikar

et al. 2017

Int J Basic Clin Pharmacol

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Background: Pharmacovigilance has evolved as an important tool for dealing with Adverse Drug Reactions (ADRs) both in pre-marketing and post-marketing scenario. Underreporting of ADRs at our Adverse drug reaction Monitoring Centre (AMC) led us to conduct this study to assess Knowledge, Attitude and Practice (KAP) of the practicing clinicians at our tertiary care Pt. J.N.M. Medical College associated Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India, towards ADRs reporting.Methods: This was a cross-sectional study using pretested questionnaires consisting of 29 questions related to KAP of the practicing clinicians at Pt. J.N.M. Medical College associated Dr. B.R.A.M. Hospital, Raipur towards ADRs reporting. The percentage of responders for each question was calculated. All statistical analysis was performed in Microsoft Office Excel 2007.Results: Out of 135 questionnaires distributed only 100 were considered for analysis, so the overall response rate was 74.07%. We calculated the result from the 100 responders. Overall 77% responders were aware of existence of ADR monitoring system in India, while only 40% were aware of its existence at their hospital. Only 8% responders had reported ADRs to the National Pharmacovigilance Centre and 10% to the Adverse drug reaction Monitoring Centre (AMC) at their hospital. Lack of knowledge about where, how and whom to report ADRs, lack of time, inability to decide what to report (known or unknown ADRs) and unavailability of ADR reporting form were the important factors discouraging them reporting ADRs.Conclusions: Creating awareness regarding ADR reporting through CMEs among practicing clinicians and early sensitization at medical undergraduate level for medical students may improve the current ADR reporting rate.

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Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and practice toward adverse drug reaction reporting among practicing clinicians at a tertiary care hospital

Todar

Agrawal

Hishikar

et al. 2017

Int J Basic Clin Pharmacol

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“…Since a layer of titanium oxide is formed on its surface, preventing the diffusion of nickel atoms, nitinol is considered a biologically inert material (Shabalovskaya 2002). Nevertheless, it should be taken into consideration that thrombotic complications can occur when implanted in small arteries (Ramot and Nyska 2007;Ramot, Nyska, and Spectre 2013).…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and Systemic Safety of a Novel Implantable Annuloplasty Ring for the Treatment of Mitral Regurgitation in a Minipig Model

Ramot

Rousselle²,

Yellin

et al. 2016

Toxicol Pathol

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Prosthetic annuloplasty rings are a common treatment modality for mitral regurgitation, and recently, percutaneous implantation techniques have gained popularity due to their favorable safety profile. Although in common use, biocompatibility of annuloplasty rings has been reported only sparsely in the literature, and none of these reports used the percutaneous technique of implantation. We report on the biocompatibility and the systemic safety of a novel transcatheter mitral valve annuloplasty ring (AMEND™) in 6 minipigs. This device is composed of a nitinol tube surrounded by a braided polyethylene terephthalate fabric tube. The device produced no adverse inflammatory response, showing gradual integration between the metal ring and the fabric by normal host fibrocellular response, leading to complete neoendocardium coverage. There was no evidence for adverse reactions, rejection, or intolerance in the valvular structure. In 2 animals, hemopericardium resulted from the implantation procedure, leading to rightsided cardiac insufficiency with pulmonary edema and liver congestion. The findings reported herein can serve as a case study for the expected healing pathology reactions after implantation of transcatheter mitral valve annuloplasty rings.

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“…It also negatively interferes with the production of nitric oxide [18]. In addition, it leads to DNA damage, blocking of ATP and release of proapoptotic proteins.…”

Section: Mechanisms Of Drug Cardiotoxicity and Other Chemical Substancesmentioning

confidence: 99%

s Myocardial infarction caused by pharmacological substances – case description and literature review

Kameczura¹,

Bryniarski²,

Surowiec³

et al. 2013

pwki

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Myocardial infarction (MI) is most commonly caused by atherosclerosis and/or inflammatory processes of coronary artery walls. The consequence of those phenomena is instability of the atherosclerotic plaque, activation of the coagulation cascade and thrombus formation which occludes the lumen of the vessel. Vasospasm and microembolisation may participate in MI pathogenesis. In young individuals with diagnosis of MI, coronarography often reveals no pathologies. Is reported that MIs without significant changes of the coronary arteries occur in 1% to 12% of patients. In this article we focus on chemical substances, medicines among them, which can be a cause of MI.

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Drug-Induced Thrombosis—Experimental, Clinical, and Mechanistic Considerations

Cited by 40 publications

References 119 publications

Knowledge, attitude and practice toward adverse drug reaction reporting among practicing clinicians at a tertiary care hospital

Knowledge, attitude and practice toward adverse drug reaction reporting among practicing clinicians at a tertiary care hospital

Biocompatibility and Systemic Safety of a Novel Implantable Annuloplasty Ring for the Treatment of Mitral Regurgitation in a Minipig Model

s Myocardial infarction caused by pharmacological substances – case description and literature review

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