2008
DOI: 10.1590/s0102-695x2008000400006
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Abstract: RESUMO: "Toxicidade aguda de extrato de raízes de Brosimum gaudichaudii Trécul. em camundongos: determinação da dose letal aproximada e da dose letal mediana". O Brosimum gaudichaudii Trécul. (BG) família Moraceae, é largamente distribuído nas regiões de cerrado do Brasil e é popularmente conhecido como "mamacadela" e possui, na sua composição química, furocumarinas fotossensibilizantes. O principal uso terapêutico do BG é no tratamento do vitiligo, uma doença despigmentante da pele com prevalência de aproxima… Show more

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Cited by 10 publications
(8 citation statements)
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“…In the initial stage of this OXL study, acute toxicity was tested, which represents a first step in the toxicological investigation of an unknown substance, with the determination of LD 50 , being the indicator of acute toxicity (Lorke 1983). This step is extremely important as it can help to avoid or prevent potential organ damage during treatments of animals in testing (Cunha et al 2008). The LD 50 of OXL stipulated at 721 mg/kg, with confidence limits between 681 and 765 mg/kg body weight provides a good safety margin for standardization of doses of 50, 100, and 150 mg/kg to be used in mice, by intraperitoneal route, in subsequent testing.…”
Section: Discussionmentioning
confidence: 99%
“…In the initial stage of this OXL study, acute toxicity was tested, which represents a first step in the toxicological investigation of an unknown substance, with the determination of LD 50 , being the indicator of acute toxicity (Lorke 1983). This step is extremely important as it can help to avoid or prevent potential organ damage during treatments of animals in testing (Cunha et al 2008). The LD 50 of OXL stipulated at 721 mg/kg, with confidence limits between 681 and 765 mg/kg body weight provides a good safety margin for standardization of doses of 50, 100, and 150 mg/kg to be used in mice, by intraperitoneal route, in subsequent testing.…”
Section: Discussionmentioning
confidence: 99%
“…Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii dii Trécul (Moraceae) is a bush that can reach up to 4 meters in height, endemic to the Brazilian savannah, popularly known as "mama-cadela", and has a high concentration of furanocoumarins in its roots [11]. Pozetti found that B. gaudichaudii has numerous potential pharmacological applications, such as anthelmintic, antimicrobial, antitumoral, and photosensibilizing [12].…”
Section: Introductionmentioning
confidence: 99%
“…Brosimum gaudichaudii, Trécul, popularly known as mama-cadela was the most frequently cited species, which was mentioned in the preparation of three medicine bottled. Studies about this species refer action to treatment of vitiligo (Filho et al, 2015) and other studies support the morphoanatomical, immunohistochemical, physiochemical, phenological, pharmacological, and toxicological aspects of the species (Martins et al, 2015;Land et al, 2017;Filho et al, 2015;Faria et al, 2015;Barbosa et al, 2014;Jacomassi et al, 2007;Cunha et al, 2008;Pozetti, 2005).…”
Section: Resultsmentioning
confidence: 85%