2016
DOI: 10.1080/13880209.2016.1228682
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Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide

Abstract: The tested doses of OXL were safe, with no motor impairment, and show clear antinociceptive and anticonvulsant potential. Future investigations with this monoterpene may lead to the development of a new molecule with even higher potency and selectivity.

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Cited by 38 publications
(19 citation statements)
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“…Linalool oxide, identified as sodiated ion at m/z 193.11975, is a common, prominent peak of SEO1, 2 and 3, while barely detected in the commercial oil SEOT from a population grown in Albania already shown/found to be a linalool poor chemotype [21]. Although the pharmaceutical anxiolytic activity [45] is related to the non-oxygenated precursor linalool, linalool oxide has shown additional antinociceptive and anticonvulsant effects on animal models [10], pointing to a higher biological potential of SEO1, 2, and 3 with respect to SEOT. Conversely, SEOT is rich in choline (m/z 104.10701), an essential nutrient revealed also in SEO2 and SEO3.…”
Section: Ms Metabolite Profilingmentioning
confidence: 99%
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“…Linalool oxide, identified as sodiated ion at m/z 193.11975, is a common, prominent peak of SEO1, 2 and 3, while barely detected in the commercial oil SEOT from a population grown in Albania already shown/found to be a linalool poor chemotype [21]. Although the pharmaceutical anxiolytic activity [45] is related to the non-oxygenated precursor linalool, linalool oxide has shown additional antinociceptive and anticonvulsant effects on animal models [10], pointing to a higher biological potential of SEO1, 2, and 3 with respect to SEOT. Conversely, SEOT is rich in choline (m/z 104.10701), an essential nutrient revealed also in SEO2 and SEO3.…”
Section: Ms Metabolite Profilingmentioning
confidence: 99%
“…In the Lamiaceae species, that can be considered as one of the richest in medicinal plant [7], Satureja essential oil (SEO) provides the basis for a wide range of biological and industrial applications with antiseptic, antioxidant, antifungal, carminative, and digestive properties [8,9], thanks to the content of biologically active phytochemicals. Furthermore, it is often used in Mediterranean cooking preparations and even as natural antibacterial agent in food packaging [10,11]. Recently, natural substances such as essential oils have attracted the attention of researchers due to their great beneficial effects [12,13].…”
Section: Introductionmentioning
confidence: 99%
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“…Similar to linalool, OXL (50, 100 and 150 mg/kg, i.p.) did not cause either muscle relaxation or motor coordination deficits at any of the doses tested [225].…”
Section: Linaloolmentioning
confidence: 73%
“…Being a rich source for bioactive molecules, medicinal plants provide hope for development of novel antidepressant drugs [ 8 , 9 , 10 ]. An alternative approach might come from aromatic plants.…”
Section: Pharmacological Management Of Major Depressionmentioning
confidence: 99%