Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide

Souto-Maior, Flávia Negromonte; Fonsêca, Diogo Vilar da; Salgado, Paula Regina Rodrigues; Monte, Lucas de Oliveira; Sousa, Damião Pergentino de; Almeida, Reinaldo Nóbrega de

doi:10.1080/13880209.2016.1228682

Cited by 39 publications

(26 citation statements)

References 41 publications

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“…Linalool oxide, identified as sodiated ion at m/z 193.11975, is a common, prominent peak of SEO1, 2 and 3, while barely detected in the commercial oil SEOT from a population grown in Albania already shown/found to be a linalool poor chemotype [21]. Although the pharmaceutical anxiolytic activity [45] is related to the non-oxygenated precursor linalool, linalool oxide has shown additional antinociceptive and anticonvulsant effects on animal models [10], pointing to a higher biological potential of SEO1, 2, and 3 with respect to SEOT. Conversely, SEOT is rich in choline (m/z 104.10701), an essential nutrient revealed also in SEO2 and SEO3.…”

Section: Ms Metabolite Profilingmentioning

confidence: 99%

“…In the Lamiaceae species, that can be considered as one of the richest in medicinal plant [7], Satureja essential oil (SEO) provides the basis for a wide range of biological and industrial applications with antiseptic, antioxidant, antifungal, carminative, and digestive properties [8,9], thanks to the content of biologically active phytochemicals. Furthermore, it is often used in Mediterranean cooking preparations and even as natural antibacterial agent in food packaging [10,11]. Recently, natural substances such as essential oils have attracted the attention of researchers due to their great beneficial effects [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…The volatile fraction is mainly characterized by oxygenated monoterpenes, e.g., thymol and carvacrol, whose amount can be assumed as an indicator of the antimicrobial activity [14], and both open-chain and monocyclic monoterpenes with an allelopathic effect [15]. Notably, carvacrol has been approved for food use and classified as GRAS (generally recognized as safe) [16], while non-oxygenated monoterpenes, such as linalool and p-cymene, have shown analgesic effect [10]. A high content of the latter has been also associated with a significant role in plant protection from the herbivores [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

et al. 2019

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Chemical fingerprints of four different Satureja montana L. essential oils (SEOs) were assayed by an untargeted metabolomics approach based on Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) coupled with either electrospray ionization or atmospheric pressure chemical ionization ion sources. Analysis and relative quantification of the non-polar volatile fraction were conducted by gas chromatography (GC) coupled to MS. FT-ICR MS confirmed significant differences in the polar metabolite composition, while GC-MS analyses confirmed slight fluctuations in the relative amount of major terpenes and terpenoids, known to play a key role in antimicrobial mechanisms. Oil in eater (O/W) nanoemulsions (NEs) composed by SEOs and Tween 20 or Tween 80 were prepared and analyzed in terms of hydrodynamic diameter, ζ-potential and polydispersity index. The results confirm the formation of stable NEs homogeneous in size. Minimum inhibitory and minimum bactericidal concentrations of SEOs were determined towards Gram-positive (Listeria monocytogenes, Staphylococcus aureus, Staphylococcus haemolyticus) and Gram-negative clinical isolates (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens). Commercial SEO showed strongest antibacterial activity, while SEO 3 was found to be the most active among the lab made extractions. MIC and MBC values ranged from 0.39 to 6.25 mg·mL−1. Furthermore, a SEO structured in NEs formulation was able to preserve and improve antimicrobial activity.

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Section: Ms Metabolite Profilingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

et al. 2019

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“…Similar to linalool, OXL (50, 100 and 150 mg/kg, i.p.) did not cause either muscle relaxation or motor coordination deficits at any of the doses tested [225].…”

Section: Linaloolmentioning

confidence: 73%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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“…Being a rich source for bioactive molecules, medicinal plants provide hope for development of novel antidepressant drugs [ 8 , 9 , 10 ]. An alternative approach might come from aromatic plants.…”

Section: Pharmacological Management Of Major Depressionmentioning

confidence: 99%

Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

Sousa

Silva

et al. 2017

Molecules

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Depression is a disease that has affected a high proportion of the world’s population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are discussed. The mechanisms of action of the oils and the presence of psychoactive constituents in their chemical compositions are discussed. The data in the review show the therapeutic potential of essential oils and their chemical constituents for use in depressive disorders. Advanced studies using humans are needed to confirm the antidepressant properties described in animals.

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Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide

Abstract: The tested doses of OXL were safe, with no motor impairment, and show clear antinociceptive and anticonvulsant potential. Future investigations with this monoterpene may lead to the development of a new molecule with even higher potency and selectivity.

Cited by 39 publications

References 41 publications

Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

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