Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

Sousa, Damião Pergentino de; Silva, Rayanne H. N.; Silva, Epifanio F da; Gavioli, Elaine C.

doi:10.3390/molecules22081290

Cited by 34 publications

(18 citation statements)

References 78 publications

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“…renders the antidepressant-like actions via inhibiting monoamine neurotransmission (MAO-A) at the lethal dose (LD50 = 4.5 g/kg) in mice. Moreover, repeated administration of eugenol decreased immobility in the FST and tail suspension test (TST) in a dose-dependent mode in mice [19] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

2019

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Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease. In the present study we designed and synthesized the eugenol based derivatives and investigated them for human MAO inhibitory potential as promising candidates for therapeutics of neurological disorders. Moreover, radical scavenging activity of designed derivatives was tested by and H 2 O 2 and DPPH scavenging methods. Eugenol based derivatives were designed and synthesized for human MAO inhibitory action. The in silico and in vitro models were utilized for the evaluation of hMAO inhibition. The insight into molecular interactions among the compounds and both hMAO-A and hMAO-B active site was achieved by molecular docking studies. The two spectrophotometric titrations techniques were used to evaluate antioxidant potential. Compounds 5b and 16 were found as most active hMAO-A inhibitors with IC 50 values of 5.989 ± 0.007 µM and 7.348 ± 0.027 µM respectively, through an appreciable selectivity index value of 0.19 and 0.14 respectively. In case of hMAO-B inhibition compounds 13a and 13b were found as most active hMAO-B inhibitors with IC 50 values of 7.494 ± 0.014 µM and 9.183 ± 0.034 µM receptively and outstanding value of selectivity index of 5.14 and 5.72 respectively. Radical scavenging assay showed that compounds 5b , 5a , 9b , 9a were active antioxidants. The findings of present study indicated excellent correlation among dry lab and wet lab hMAO inhibitory experiments. Interestingly, the compounds exhibiting better MAO inhibition activity was also appeared as good antioxidant agents.

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Section: Introductionmentioning

confidence: 99%

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

2019

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“…Because of their anti-oxidative stress, anti-inflammatory, antibacterial and anti-tumor effects, EOs are widely used in the prevention and treatment of various cardiovascular diseases 47,48 . Previous investigations about EOs have already demonstrated that the mixture containing more than one EO can evoke synergic actions to exhibit some greater benefits 49 . In present reports, the synergistic effect of different EOs determines that CEOs have a better effect.…”

Section: Discussionmentioning

confidence: 99%

The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

Dong

Sun

et al. 2019

Sci Rep

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Epidemiological researches have demonstrated the relationship between PM 2.5 exposure and increased morbidity and mortality of cardiovascular injury. However, no effective therapeutic method was established. The purpose of this study is to investigate the effect of acute PM 2.5 exposure on the mice heart tissue and explore the therapeutic effects of compound essential oils (CEOs) in this model. In this study, after mice were exposed to PM 2.5 intratracheally, some obvious histopathological changes as well as some great alterations of proinflammatory cytokines were observed in the heart tissue. The imbalance of oxidative stress, the altered Ca 2+ channel related proteins and the increased intracellular free Ca 2+ were all involved in the heart impairment and would also be investigated in this model. The CEOs alleviated the heart impairment via its antioxidant effect rather than its anti-inflammatory function because our results revealed that oxidative stress related indicators were restored after CEOs administration. At the same time, increased concentration of intracellular free Ca 2+ and ROS induced by PM 2.5 were reduced after NAC (N-Acetyl-L-cysteine) administration. These data suggested that the acute PM 2.5 exposure would damage heart tissue by inducing the inflammatory response, oxidative stress and intracellular free Ca 2+ overload. PM 2.5 -induced oxidative stress probably increase intracellular free Ca 2+ via RYR2 and SERCA2a. CEOs have the potential to be a novel effective and convenient therapeutic method to prevent and treat the acute heart impairment induced by PM 2.5 via its antioxidant function.

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“…Essential oils are natural products that demonstrate high therapeutic potential against various types of pathologies, including central nervous system (CNS) disorders. Their chemical constituents exhibit various pharmacological activities such as anxiolytic [8], antidepressant [9], analgesic [10], anticonvulsant [11], and inhibitory effects against brain tumor cells [12]. Monoterpenes are compounds commonly found in essential oils that have received much attention as a potential therapy for AD [13].…”

Section: Introductionmentioning

confidence: 99%

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hrițcu

Boiangiu

Morais

et al. 2020

BioMed Research International

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Alzheimer’s disease (AD) could be considered a multifactorial neurodegenerative disorder characterized by the accumulation of the β-amyloid-peptide (Aβ) within the brain leading to cognitive deficits, oxidative stress, and neuroinflammation. The present work was carried out to investigate the neuroprotective effect of (-)-cis-carveol (1% and 3%, for 21 days) against the β-amyloid-peptide 1-42- (Aβ1-42-) induced AD. Twenty-five rats were divided into five groups (n=5/group): the first group—control (sham-operated); the second group—Aβ1-42 (1 mM) that received donepezil treatment (5 mg/kg, as the positive reference drug in the Y-maze and the radial arm maze tests); the third group—Aβ1-42 (1 mM); the fourth and fifth groups—Aβ1-42 (1 mM) that received (-)-cis-carveol treatment groups (1% and 3%). The results of this study demonstrated that (-)-cis-carveol improved Aβ1-42-induced memory deficits examined by using Y-maze and radial arm maze in vivo tests. Also, the biochemical analyses of the hippocampus homogenates showed that (-)-cis-carveol reduced hippocampal oxidative stress caused by Aβ1-42. Our results suggested that the use of (-)-cis-carveol may be suitable for decreasing AD-related symptoms.

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Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

Cited by 34 publications

References 78 publications

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

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