2020
DOI: 10.1055/a-1087-8374
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii

Abstract: The treatment of vitiligo includes the combination of psoralens and ultraviolet type A exposure. Psoralens belong to a group of natural furanocoumarins that cause the skin to become sensitive temporarily to ultraviolet type A. The aim of this study was to develop a physiologically based pharmacokinetic model of 5-MOP from Brosimum gaudichaudii to support psoralen and ultraviolet type A therapy. A study of rats was used to establish and validate rat tissue distribution. The same chemical-specific parameters use… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
4
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
5

Relationship

2
3

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 26 publications
2
4
0
Order By: Relevance
“…Those results were corroborated with our findings where we found that the maximum expression of melanin occurred at 48 h after the start of treatment (Martins et al 2020). The current study provides an insight into the therapeutic window of B. gaudichaudii extract.…”
Section: Resultssupporting
confidence: 92%
“…Those results were corroborated with our findings where we found that the maximum expression of melanin occurred at 48 h after the start of treatment (Martins et al 2020). The current study provides an insight into the therapeutic window of B. gaudichaudii extract.…”
Section: Resultssupporting
confidence: 92%
“…Moreover, this core moiety confers enough lipophilicity to these chemicals to allow their diffusion through the skin and cross other biological barriers such as the blood-brain barrier [56]. In this work, several databases provided similar physicochemical and pharmacokinetic information about LF (Table 1 and 2), being these data also supported by empiric research found in the literature [57][58][59][60]. Notwithstanding, the correlation of the findings through PCA showcased trends by other reports, such as the molecular weight, polar surface and Log P and Log Kp B eigenvectors convergence (Figure 1).…”
Section: Figuresupporting
confidence: 75%
“…This difference may be attributed to distinct algorithms and weightings employed when imputed information was compiled [35,38,39]. Regardless of the case, Pred-Skin results were sound when compared to empiric investigations, which showcased the skin sensitizing effects of LF by different in vitro and in vivo approaches [1,3,59,60]. Care must be taken, however, because these results imply by no means that one database is more reliable than the other, considering the narrow scope of our investigation.…”
Section: Figurementioning
confidence: 89%
“…We surveyed paediatric dosing regimens used in bacteraemia due to VNS MRSA from case reports; the dosing regimens were higher than the recom- parameters should be between 0.5 and 2.0. 22,60 There is a lack of systematic analysis of appropriate dosing regimens for coadministration of antibiotics that also take into account the in vitro susceptibility information, even though β-lactam antibiotics combined with daptomycin against S. aureus has been consistently shown to produce in vitro synergistic activities. 45,[61][62][63][64] There are limitations in the current study.…”
Section: Discussionmentioning
confidence: 99%