Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis

Thomas, Merlin; Al-Gherbawe, Mushtak

doi:10.1155/2014/865909

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…In contrast to the clinical manifestations of acute myeloid leukemia, which develops in active pulmonary tuberculosis (severe intoxication syndrome) [7], in this case, the initial clinical manifestations were weakness, loss of appetite and weight loss.…”

Section: Discussioncontrasting

confidence: 66%

“…Thomas M. and AlGherbawe M. [7] reported a case of acute myeloid leukemia in a man who was started on treatment that included isoniazid, rifampicin, pyrazinamide and ethambutol for active pulmonary tuberculosis. The main symptoms of diagnostic suspicion of acute myeloid leukemia in the patient were severe neutropenia with monocytosis accompanied by severe intoxication, the manifestations of which were identical for both diseases.…”

Section: ключові словаmentioning

confidence: 99%

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Clinical manifestations and diagnosis of acute myeloid leukemia in a patient with a medical history of pulmonary tuberculosis (a case report)

Raznatovska

Shalmin

Noreiko

2020

ZMJ

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The aim is to familiarize practitioners with the initial clinical manifestations of acute myeloid leukemia and its diagnosis in a patient with a past medical history of pulmonary tuberculosis. Materials and methods.The article presents a clinical case of acute myeloid leukemia clinical manifestations based on our own clinical experience and its diagnosis in the patient with previous pulmonary tuberculosis. The patient was followed-up and diagnosed with acute myeloid leukemia in the Municipal Institution "Zaporizhzhia Regional Tuberculosis Clinical Dispensary". Results.The patient presented in this study was diagnosed with pulmonary tuberculosis and received antimycobacterial treatment including isoniazid and rifampicin, which may have initially contributed to the hematopoietic mechanisms impairment. Perhaps the stressful situation triggered the development of acute myeloid leukemia due to underlying impaired mechanisms of hematopoiesis that had occurred. In this case, the initial clinical manifestations were weakness, loss of appetite and weight loss. A clinical blood analysis with leukogram and the bone marrow biopsy with aspirate examination became priority methods in diagnosing acute myeloid leukemia.The clinical case presented primarily demonstrates patient's irresponsibility for their own health, who having symptoms such as weakness, loss of appetite, and weight loss for 5 months as well as past medical history of tuberculosis, did not seek medical advice timely. Conclusions.In a patient with a past medical history of pulmonary tuberculosis, priority task is to confirm or rule out reactivation tuberculosis. The initial clinical manifestations of acute myeloid leukemia are: unprovoked weakness for several months; increasing exertional dyspnea; anemia, leukopenia, neutropenia, ESR acceleration.

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Section: Discussioncontrasting

confidence: 66%

Section: ключові словаmentioning

confidence: 99%

Clinical manifestations and diagnosis of acute myeloid leukemia in a patient with a medical history of pulmonary tuberculosis (a case report)

Raznatovska

Shalmin

Noreiko

2020

ZMJ

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“…Immunosuppressive treatments for a number of severe childhood conditions increase the risk of mycobacterial diseases. In particular, childhood leukemia is associated with a higher risk of developing BCG , and NTM infections or TB during chemotherapy or following bone marrow transplantation (BMT). NTM, M.tb and, more rarely, BCG infections have also been observed in children treated with immunosuppressive drugs for solid organ transplantation or BMT for other conditions, such as severe aplastic anemia, myeloma, familial hemophagocytic lymphohistiocytosis or malignant infantile osteopetrosis.…”

Section: Acquired Immunodeficiencies Conferring a Predisposition To Mmentioning

confidence: 99%

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

Boisson–Dupuis

Bustamante

El-Baghdadi

et al. 2015

Immunological Reviews

192

165

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Summary Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely elusive, as only a small proportion of infected individuals develop clinical disease either during primary infection or during reactivation from latency or secondary infection. Subacute, hematogenous, and extrapulmonary disease tends to be more frequent in infants, children, and teenagers than in adults. Life-threatening primary TB of childhood can result from known acquired or inherited immunodeficiencies, although the vast majority of cases remain unexplained. We review here the conditions conferring a predisposition to childhood clinical diseases caused by mycobacteria, including not only M.tb but also weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria. Infections with weakly virulent mycobacteria are much rarer than TB, but the inherited and acquired immunodeficiencies underlying these infections are much better known. Their study has also provided genetic and immunological insights into childhood TB, as illustrated by the discovery of single-gene inborn errors of IFN-γ immunity underlying severe cases of TB. Novel findings are expected from ongoing and future human genetic studies of childhood TB in countries that combine a high proportion of consanguineous marriages, a high incidence of TB, and an excellent clinical care, such as Iran, Morocco, and Turkey.

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“…Leukocytosis associated with leukemoid reaction is transient and may return to normal when the causes are removed. Leukemoid reaction classification depends on the course of the disease and the development of hematopoietic irritation into myeloid (neutrophilic), leukemoid reaction, lymphoid leukemoid reaction, eosinophilic leukemoid reaction, monocytic leukemoid reaction and basophilic leukemoid reaction [ 25 ]. Leukemoid reactions resembles chronic myeloid leukemia or chronic neutrophilic leukemia; they may take place in TB, septicemia and acute megaloblastic anemia during pregnancy.…”

Section: Rare Hematological Manifestations In Active Tbmentioning

confidence: 99%

“…Leukemoid reactions resembles chronic myeloid leukemia or chronic neutrophilic leukemia; they may take place in TB, septicemia and acute megaloblastic anemia during pregnancy. These hematologic manifestations rarely occur, usually in patients with extrapulmonary manifestations or disseminated TB and more frequently in older males [ 24 , 25 ].…”

Section: Rare Hematological Manifestations In Active Tbmentioning

confidence: 99%

Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art

et al. 2021

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Background: Tuberculosis (TB) can seriously affect the hematopoietic system, with involvement of both myeloid and lymphoid cell lines as well as plasma components. These hematological changes act as a marker for the diagnosis, prognosis and response to therapy. Methods: We searched PubMed, Scopus, Google Scholar, EMBASE, Cochrane Library and WHO websites from 1950 to May 2021 for papers on the interaction between TB and common and rare hematological manifestation. Results: Hematological reactions in patients with TB are possible in both young and old women and men but seem more frequent in the elderly, and they can be predictors of both diagnosis and worse outcome for TB, regardless of whether it is pulmonary, extra pulmonary or miliary. Even anti-TB therapies can cause hematological adverse events, among which some are serious and rare and can compromise the patient’s recovery pathway to completing treatment. Conclusion: Hematological screening and follow-up, including complete blood count and coagulation, are always necessary both at the diagnosis of TB and during antitubercular treatment in order to monitor hematological parameters. Short therapy regimens for multidrug-resistant TB (MDR-TB) may also be useful for reducing hematological toxicity, especially in contexts where this cannot be monitored. Close monitoring of drug interactions and hematological adverse events is always recommended.

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Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis

Cited by 4 publications

References 12 publications

Clinical manifestations and diagnosis of acute myeloid leukemia in a patient with a medical history of pulmonary tuberculosis (a case report)

Clinical manifestations and diagnosis of acute myeloid leukemia in a patient with a medical history of pulmonary tuberculosis (a case report)

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art

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