Acute Infectious Mononucleosis and Hodgkin's Disease Occurring Simultaneously in the Same Patient

Hodgkin's Disease in Patients with Previous Infectious Mononucleosis: 30 Years' Experience

“…Hodgkin's disease can cause false-positive Paul-Bunnell reactions (Massey et al, 1953;Kenis et al, 1958). We found two patients with positive Paul-Bunnell reactions when first seen with Hodgkin's disease.…”

The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints

“…42 While T cells in CHL are rendered incapable of mediating anti-tumor responses, there is some evidence to suggest that they may actually support RS cell growth and survival. CHL has been noted to develop during the immune response to active viral infections, such as acute Epstein-Barr virus mediated mononucleosis, 43 and during immune reconstitution following the initiation of antiretroviral therapy in HIV+ patients. 44 Mechanistically, T cells in CHL can promote RS cell survival and proliferation via CD40/CD40 ligand-mediated alternative activation of NF-kB; 45 this growth signal may be particularly important for the survival of RS cells, which have lost the ability to activate NF-kB through conventional B cell receptor-driven signals.…”

Infectious Mononucleosis in Hodgkin’s Disease

“…Serious doubts have therefore been cast on any specific or causal role for EBV in HD. This view gains support from the few descriptions of the simultaneous presentation of the two disorders [4,10], and even more, from the recent and previously unreported development of IM in a pa tient who, 3 years previously had undergone curative treatment for HD [7]. The purpose of this brief communication is to report the occurrence of IM in a further patient with established HD.…”