Infectious Mononucleosis in Hodgkin’s Disease

Davidson, Robert J.; Lessels, S.E.

doi:10.1159/000207874

Cited by 5 publications

(4 citation statements)

References 9 publications

(11 reference statements)

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“…Thus, several investigators have found higher titres of EBV-antibodies in patients with H D than in healthy controls (Henle and Henle, 1973;Langenhuysen et al, 1974;Hesse et al, 1977), but this may be due to the inability of patients with H D to control chronic latent infections with herpesvirus. Moreover, EBV-antibodies are not found in all patients with HD, and some studies have shown similar proportion of past EBV infection in patients with H D as compared to appropriate controls (Goldman and Aisenberg, 1970 Davidson and Lessels, 1977). However, H D may be a heterogenous disease, and if EBV plays a role in the aetiology of the disease, it can obviously be of importance only in a proportion of the patients with HD.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, EBV-antibodies are not found in all patients with HD, and some studies have shown similar proportion of past EBV infection in patients with H D as compared to appropriate controls (Goldman and Aisenberg, 1970;Henle and Henle, 1973;Langenhuysen et al, 1974;Hesse et al, 1977;Lange et al, 1978). A few cases of IM in patients with H D have also been reported (Kenis et at., 1958;Langenhuysen, 1976;Davidson and Lessels, 1977). However, H D may be a heterogenous disease, and if EBV plays a role in the aetiology of the disease, it can obviously be of importance only in a proportion of the patients with HD.…”

Section: Discussionmentioning

confidence: 99%

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Hodgkin's disease in patients with previous infectious mononucleosis

Kvåle

Høiby²,

Pedersen

1979

Intl Journal of Cancer

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Patients with a positive reaction to the Paul-Bunnell test in the period 1961-72 were identified at nine different laboratories in Norway and matched against cases of malignant lymphoma registered at the Cancer Registry of Norway in the period 1961-75. Among 5,840 patients having a positive Paul-Bunnell test a total of six developed malignant lymphoma, three of these more than 1 year after the positive Paul-Bunnell test. The expected number of malignant lymphoma was 2.04. Of the six lymphoma cases, five were classified as Hodgkin's disease (HD). The present investigation agrees well with the findings of other epidemiological studies. There seems to be a small excess in incidence of HD among patients with previous infectious mononucleosis (IM), but both diagnostic problems and possible confounding factors must be taken into account before a possible causal association is considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hodgkin's disease in patients with previous infectious mononucleosis

Kvåle

Høiby²,

Pedersen

1979

Intl Journal of Cancer

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“…Both Hodgkin's disease and infectious mononucleosis occur preferentially in higher socioeconomic groups, for example (McMahon 1966;Gutensohn and Cole 1981), and the possibility of an independent association on this basis arises. Not all patients with Hodgkin's disease possess antibodies to EBV [infectious mononucleosis following Hodgkin's disease has been reported (Davidson and Lessles 1977)]; and whereas some patients with Hodgkin's disease may have elevated anti-VCA and anti-EBNA titres, this characteristic appears to be secondary to immunosuppression rather than indicating a direct association between Hodgkin's disease and EBV infection (Hesse et al 1977;Mochanko et al 1979). Neither EBV DNA nor EBNA has been detected in Hodgkin's tissue or cultured Reed-Sternberg cells (Nonoyama et al 1974;Gallo and Geimann 1981).…”

Section: Infectious Mononucleosis and Hodgkin's Diseasementioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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“…Although in many cases of HD serum titers against EBV are somewhat increased [4,5], some cases of HD show no antibody evidence of EBV infection. Serious doubts as to any specific role for EBV in HD come from cases with established HD in which IM occurred during the course of the disease [6,7]. The purpose of this communication is to show by DNA analysis of the tumor cells-searching for EBV genomes--that, although HI) developed shortly alter IM and antibody response to EBV was compatible with the convalescent phase of IM, EB-viral infection most likely may not be directly oncogenic but rather may contribute to an immunologic state which in turn predisposes to malignancy.…”

Section: Hodgkin's Disease Mononucleosismentioning

confidence: 99%