Hodgkin's Disease in Patients with Previous Infectious Mononucleosis: 30 Years' Experience

Rosdahl, N; So, Larsen; Clemmesen, J

doi:10.1136/bmj.2.5913.253

Cited by 126 publications

(48 citation statements)

References 13 publications

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“…In the case of HL, several findings support the notion that EBV may be involved in the pathogenesis of this disease: 1) an approximately threefold increase in the occurrence of HL after infectious mononucleosis [26], 2) the increase in antibody titers to EBV both before and after the onset of lymphoma [10], and 3) the finding of a monoclonal pattern of EBV infection in HL tissue [2]. However, the precise pathogenic role of this virus is unclear, as the mechanism of cell malignization has not been demonstrated [17].…”

Section: Introductionmentioning

confidence: 80%

The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil

et al. 2006

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Pediatric Hodgkin lymphoma (HL) occurring in developing regions is different from HL in industrialized countries due to the higher frequency of association with Epstein-Barr virus (EBV) infection. This infection is related to classical HL (cHL) but is virtually absent in nodular lymphocyte predominant HL (nLPHL). We studied the phenotype and the expression of EBV gene products in 90 pediatric cases by immunohistochemistry and in situ hybridization. EBV-positive tumor cells were found exclusively in cHL. The infection occurred with high frequency in all cHL subtypes, but it predominated in the mixed cellularity and lymphocyte depletion subtypes. These results reinforce the hypothesis that EBV plays a major role in the etiology of pediatric cHL in developing areas. Curiously, the frequency of EBV infection in HL was identical to the previously described for Burkitt's lymphoma in the same pediatric population. As both lymphomas have a postulated precursor cell in the germinal center (GC), the pattern of latently EBV-infected GC cells previously described in Bahia may be related to the development of these lymphomas.

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Section: Introductionmentioning

confidence: 80%

The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil

et al. 2006

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“…20,21 Some studies reported that the immune-related disorders like rheumatoid arthritis have an elevated risk of subsequent HL, 40-43 but this was not confirmed in this data. 20 Several studies have reported an increased risk of HL after infectious mononucleosis, [44][45][46] which is associated with Epstein-Barr virus, but did not observe significant association between HL and infectious mononucleosis [OR adj of 1.30 (p = 0.36)]. 21 The infectious mononucleosis was retained in the final multivariate model because of its biological importance to the etiology of HL.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Karunanayake

Spinelli

McLaughlin

et al. 2012

Journal of Agromedicine

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The objective of this study was to investigate the putative associations of specific pesticides with Hodgkin lymphoma. A population-based, case-control study of Hodgkin lymphoma was conducted among males in six regions of Canada. Data were collected by a mailed questionnaire followed by a telephone interview to obtain detailed exposures data for those reporting ≥ 10 hours per year of pesticide exposure. Conditional logistic regression was used to fit statistical models. Comparisons of 316 Hodgkin lymphoma cases and 1506 controls identified several factors as predictors for increased Hodgkin lymphoma risk: family history of cancer, exposure to the insecticide chlorpyrifos [OR (95% CI) = 1.19 (1.03, 1.37)], and previous diagnosis of acne or shingles. The increased risk of developing Hodgkin lymphoma detected among Canadian men who used chlorpyrifos must be interpreted cautiously; however the strength of its association indicates that it requires investigation in other populations.

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“…A number of epidemiological studies supported this view (Carter and Penman, 1969; Beebe Connelly and Christine, 1974;Rosdahl et al, 1974;Munoz et al, 1978;Kvale et al, 1979), and as can be seen in Table IV, the increased relative risk (RR) of developing Hodgkin-type lymphoma varies from 2 to 5 for people who have had 1M as compared to the general population. Worth noting is the relatively short time interval elapsing between 1M and HD: 2-11 years, with a mean of approximately 3 years, 95% of the cases occurring within 7 years.…”

Section: E Infectious Mononucleosis As a Risk Factor For Hodgkin's Dmentioning

confidence: 77%

Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

de-Thé

1982

The Herpesviruses

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Hodgkin's Disease in Patients with Previous Infectious Mononucleosis: 30 Years' Experience

Cited by 126 publications

References 13 publications

The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil

The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil

Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study

Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

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