Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

de-Thé, G

doi:10.1007/978-1-4684-4163-5_2

Cited by 96 publications

(32 citation statements)

References 206 publications

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“…EBV viral capsid antigen and DNase antigens are expressed in the lytic phase of EBV infection (4). Elevated serum levels of antibodies against these two antigens may reflect the reactivation of EBV in humans (14). The nasopharyngeal carcinoma risk was significantly associated with anti -EBV viral capsid antigen immunoglobulin A at low and high serum levels but with anti -EBV DNase only at high level.…”

Section: Discussionmentioning

confidence: 93%

“…In our previous cohort study, participants seropositive for either one or both anti-EBV markers, anti -EBV viral capsid antigen immunoglobulin A and anti -EBV DNase, had an increased nasopharyngeal carcinoma risk, showing multivariate-adjusted hazard ratios [95% confidence interval (95% CI)] of 4.0 (1.6-10.2) and 32.8 (7.3-147.2), respectively, compared with the seronegatives of both markers (13). Elevated serum level of various anti-EBVs may reflect the repeated reactivation of EBV (14). Although anti-EBV seropositivity is closely associated with nasopharyngeal carcinoma, only few case-control studies have evaluated the biological gradient of nasopharyngeal carcinoma risk with increasing serum levels of anti-EBVs (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Independent Effect of EBV and Cigarette Smoking on Nasopharyngeal Carcinoma: A 20-Year Follow-Up Study on 9,622 Males without Family History in Taiwan

Hsu

Chen

Chien

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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This study aimed to assess independent effects of EBV and cigarette smoking on nasopharyngeal carcinoma, which have never been assessed in long-term followup studies. A cohort of 9,622 men was enrolled from 1984 to 1986. Blood samples collected at study entry were tested for antibodies against EBV antigens (anti-EBV) viral capsid antigen immunoglobulin A and DNase. The cigarette smoking habit was inquired through questionnaire interview. Newly developed nasopharyngeal carcinoma cases were ascertained through computerized linkage with national cancer registry profile. Cox's proportional hazard regression analysis was used to estimate multivariate-adjusted hazard ratio with its 95% confidence interval (95% CI). During the follow-up of 173,706 person-years, 32 pathologically confirmed nasopharyngeal carcinoma cases were identified >1 year after recruitment. Increasing serum levels of anti -EBV viral capsid antigen immunoglobulin A and DNase were significantly associated with nasopharyngeal carcinoma risk in a dose-response relationship.The multivariate-adjusted hazard ratio (95% CI) of developing nasopharyngeal carcinoma for low and high antibody levels compared with seronegatives was 9.5 (2.2-40.1) and 21.4 (2.8-161.7), respectively, for anti -EBV viral capsid antigen immunoglobulin A (P < 0.001 for trend), and 1.6 (0.5-4.6) and 16.0 (5.4-47.1), respectively, for anti -EBV DNase (P < 0.001 for trend). The shorter the time interval between study entry and nasopharyngeal carcinoma diagnosis, the higher was the proportion of anti -EBV viral capsid antigen immunoglobulin A among nasopharyngeal carcinoma patients. The multivariate-adjusted hazard ratio (95% CI) was 3.0 (1.3-7.2) for z30 pack-years of cumulative cigarette smoking compared with <30 pack-years as the reference. The longer and heavier the cigarette smoking habit, the higher was the nasopharyngeal carcinoma risk. Anti -EBV viral capsid antigen immunoglobulin A, anti -EBV DNase, and long-term heavy cigarette smoking are independent nasopharyngeal carcinoma risk predictors. (Cancer Epidemiol Biomarkers Prev 2009;18(4):1218 -26)

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Independent Effect of EBV and Cigarette Smoking on Nasopharyngeal Carcinoma: A 20-Year Follow-Up Study on 9,622 Males without Family History in Taiwan

Hsu

Chen

Chien

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…NPC is a major health problem in South-East Asia and North Africa, with an incidence of 5-40 per 100,000 individuals. [2][3][4] Its association with EBV is constant except in a few atypical highly differentiated cases. 5,6 About 5-20% of gastric carcinoma, a widespread cancer, are associated with EBV.…”

Section: Introductionmentioning

confidence: 99%

Structure of the Epstein-Barr Virus Oncogene BARF1

Tarbouriech

Ruggiero

Turenne-Tessier

et al. 2006

Journal of Molecular Biology

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“…High-risk areas are restricted to southern China, Hong Kong and south-east Asian countries, including Taiwan, Singapore, Malaysia, Indonesia and Vietnam (de Thé, 1982). Intermediate risk areas are confined to Alaska and north Africa, including Algeria, Morocco and Tunisia.…”

Section: Introductionmentioning

confidence: 99%

Amino acid changes in functional domains of latent membrane protein 1 of Epstein–Barr virus in nasopharyngeal carcinoma of southern China and Taiwan: prevalence of an HLA A2-restricted ‘epitope-loss variant’

Lin

Cherng²,

Lin³

et al. 2004

Journal of General Virology

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Full-length sequences of the Epstein-Barr virus (EBV) gene for latent membrane protein (LMP)-1 from 22 nasopharyngeal carcinoma (NPC) biopsy specimens and 18 non-neoplastic counterparts (NPI) were determined. Relative to the B95-8 strain, the amino acid sequences of the toxic-signal and transformation domains were changed variably in NPC and NPI specimens; in contrast, no change was observed in the NF-kB (nuclear factor kB) activation domain. HLA typing revealed that 47 % of NPC and 31 % of NPI specimens were HLA A2-positive. A major A2-restricted epitope within LMP-1 (residues 125-133) was analysed. At residue 126, a change of LRF was detected in 91 % (20/22) of NPC and 67 % (12/18) of NPI specimens. In addition, a deletion at residue 126 was detected in one NPC sample from Taiwan. At residue 129, a change of MRI was observed in all samples, regardless of whether they were NPC or NPI. The changes in this peptide between NPC and NPI specimens, including mutation and deletion, are statistically significant (P<0?05). A recent report indicated that this variant sequence is recognized poorly by epitope-specific T cells. Genotyping results indicated that 96 % of NPC and 67 % of NPI samples carried a type A virus. By scanning the entire sequence of LMP-1, eight distinct patterns were identified. Detailed examination of these patterns revealed that type A strains are more prevalent in NPC than in NPI specimens and are marked by the loss of an XhoI site, the presence of a 30 bp deletion and the presence of a mutated, A2-restricted, T cell target epitope sequence. These results suggest that an EBV strain carrying an HLA A2-restricted 'epitope-loss variant' of LMP-1 is prevalent in NPC in southern China and Taiwan.

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Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

Cited by 96 publications

References 206 publications

Independent Effect of EBV and Cigarette Smoking on Nasopharyngeal Carcinoma: A 20-Year Follow-Up Study on 9,622 Males without Family History in Taiwan

Independent Effect of EBV and Cigarette Smoking on Nasopharyngeal Carcinoma: A 20-Year Follow-Up Study on 9,622 Males without Family History in Taiwan

Structure of the Epstein-Barr Virus Oncogene BARF1

Amino acid changes in functional domains of latent membrane protein 1 of Epstein–Barr virus in nasopharyngeal carcinoma of southern China and Taiwan: prevalence of an HLA A2-restricted ‘epitope-loss variant’

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