Acute effects of cigarette smoking on insulin resistance and arterial stiffness in young adults

Seet, Raymond C.S.; Loke, Wai Mun; Khoo, Chin Meng; Chew, Soh Eng; Chong, Wan Ling; Quek, Amy May Lin; Lim, Erle C.H.; Halliwell, Barry

doi:10.1016/j.atherosclerosis.2012.06.060

Cited by 37 publications

(20 citation statements)

References 25 publications

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“…Chronic smoking was associated with increased reactive oxygen species generation in mononuclear and polymorphonuclear cells, impairing nitric oxide bioavailability, dysfunctional NO synthase, increased consumption of NO, hypertension, activation and aggregation of platelets, changes in hemostatic components and blood lipids, a decrease in arterial collagen content, acceleration of the atherosclerotic process, and thrombosis, increasing the level of proinflammatory cytokines [5,9,11,23]. Subjects with more advanced vascular damage are more vulnerable to the acute effects of cigarette smoking [24]. Females were found to have higher mean values of total cholesterol, total lipids and phospholipids, and lower high-density lipoprotein cholesterol (HDL), and smokers, as well, higher values for total cholesterol and lipids [25].…”

Section: Discussionmentioning

confidence: 99%

Gender Differences of Arterial Stiffness and Arterial Age in Smokers

Mozoş

Maidana

Stoian

et al. 2017

IJERPH

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The present study aimed to find gender differences for arterial stiffness and arterial aging in smokers. A total of 147 smokers (71 male and 76 female, matched for age) were explored using an Arteriograph in a cross-sectional survey. Pulse wave velocity (PWV), arterial age (AA), brachial and aortic augmentation index (AixBrach, AixAo), and blood pressure variables were assessed. Data about smoking intensity, such as the number of cigarettes smoked daily, smoking period, and smoking pack years (SPY) were used. No significant differences were found for PWV, AA, AixBrach and AixAo. Significant correlations were found between SPY and PWV, augmentation indices, and AA, respectively. The cut-off values for SPY were higher for an increased arterial stiffness in male compared to female smokers (18.5 and 7.5 pack year, respectively). SPY is significantly associated with an increased arterial stiffness in smokers regardless of gender, and with an increased SBPAo only in female smokers. The results of our study indicate gender differences for arterial stiffness and arterial age in smokers.

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Section: Discussionmentioning

confidence: 99%

Gender Differences of Arterial Stiffness and Arterial Age in Smokers

Mozoş

Maidana

Stoian

et al. 2017

IJERPH

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“…Smokers had a significantly increased homeostatic model assessment insulin resistance index an hour after smoking [14]. The smoking reduced insulin mediated glucose uptake by 10% to 40% in men who smoked compared with non-smoking men [15,16].…”

Section: The Effect Of Smoking On Insulin Actionmentioning

confidence: 99%

Smoking and Type 2 Diabetes Mellitus

2012

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Cigarette smoking is a well-known risk factor in many diseases, including various kinds of cancer and cardiovascular disease. Many studies have also reported the unfavorable effects of smoking for diabetes mellitus. Smoking increases the risk of developing diabetes, and aggravates the micro- and macro-vascular complications of diabetes mellitus. Smoking is associated with insulin resistance, inflammation and dyslipidemia, but the exact mechanisms through which smoking influences diabetes mellitus are not clear. However, smoking cessation is one of the important targets for diabetes control and the prevention diabetic complications.

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“…[73] reported over 2.5 times increased risk of death in female smokers compared with nonsmokers, which was explained mainly by increased cardiovascular mortality. Hormonal responses to cigarette smoking, including growth hormone, cortisol and vasopressin, are counter-regulatory to insulin [74] and may lead to insulin resistance [75]. Nicotine may also directly inhibit insulin secretion [76].…”

Section: Smokingmentioning

confidence: 99%

State of the art paper Influence of lifestyle on the course of type 1 diabetes mellitus

Piłaciński¹,

Zozulińska-Ziółkiewicz²

2014

aoms

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Type 1 diabetes (T1DM) is an autoimmune disease that requires insulin treatment from the time of diagnosis. Its clinical course depends on both genetic and environmental factors, and the lifestyle of a patient modulates their interaction. The evidence about the influence of lifestyle on the course of T1DM is increasing. In this paper, we present evidence on the relationship between lifestyle parameters and diabetes-related outcomes. We discuss the most commonly addressed factors associated with lifestyle, such as physical activity, nutrition and smoking, and those with sparse evidence in T1DM, such as socioeconomic status, sleep duration, psychological stress and illicit drugs intake.

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Acute effects of cigarette smoking on insulin resistance and arterial stiffness in young adults

Cited by 37 publications

References 25 publications

Gender Differences of Arterial Stiffness and Arterial Age in Smokers

Gender Differences of Arterial Stiffness and Arterial Age in Smokers

Smoking and Type 2 Diabetes Mellitus

State of the art paper Influence of lifestyle on the course of type 1 diabetes mellitus

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