Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

Henke, Eugênia; Oliveira, Victória Santos; Silva, Igor Martins da; Schipper, Lucas de Lima; Dorneles, Gilson Pires; Elsner, Viviane Rostirola; Oliveira, Marcos Roberto de; Romão, Pedro R T; Peres, Alessandra

doi:10.1002/tsm2.43

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…DoIT elicited significant alterations in PC (−45%), GSH (+40%), TAC (+10%), CAT (+15%), and TBIL (−22%) therefore providing evidence that this type of protocols may be an effective tool for improving this physiological dysfunction [38]. Similar findings were observed following a 4-week HIIT protocol (2x/week, 85-90% MHR, 31.5 min, active recovery intervals) on oxidative stress and antioxidant capacity markers in postmenopausal sedentary women with obesity [58]. Furthermore, a 3-week HIIT cycling protocol totaling 22 min of pure high-intensity exercise time using 30-s bouts and 4-min active or passive recovery in active young men exhibited a reduction of 13% in PC and 26% in both TAC and CAT [13].…”

Section: Antioxidant Capacity Responsessupporting

confidence: 64%

Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial

et al. 2021

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This randomized controlled trial investigated the effects of a 5-month high-intensity hybrid-type neuromuscular training program with nontraditional implements on cardiometabolic health, redox status, and cardiovascular disease (CVD) risk in inactive overweight and obese women. Forty-nine inactive female participants with overweight and obesity (age: 36.4 ± 4.4 years; BMI: 29.1 ± 2.9 kg/m2) were randomly assigned to either a control (C, n = 21) or a training group (TR, n = 28). TR followed a 20-week supervised, progressive, time-efficient (3 days/week; 6–15 min net exercise time) program implementing loaded fundamental movement patterns with prescribed work-to-rest time intervals (20–40 s, 1:2, 1:1, 2:1) in a circuit fashion (2–3 rounds). Cardiometabolic risk factors were measured at baseline and post-training as secondary outcomes of a larger randomized controlled trial. At post-intervention, TR demonstrated favorable changes in resting heart rate (−7%, p = 0.043), high-density lipoprotein (+18.1%, p = 0.029), atherogenic index (−17%, p = 0.045), mean arterial pressure (−4.5%, p = 0.03), waist circumference (−6.2%, p = 0.005), waist-to-hip ratio (−4.6%; p = 0.015), metabolic syndrome severity score (−222%, p = 0.024), full 30-year CVD risk (−15.8%, p = 0.002) and hard 30-year CVD risk (−17.6%, p = 0.01), vascular age (−7.8%, p = 0.002), protein carbonyls (−45.7%, p = 0.001), catalase activity (+15.2%, p = 0.023), and total antioxidant capacity (+11.4%, p = 0.002) relative to C. Additionally, TR induced beneficial changes in fasting glucose (−3.4%, p = 0.002), homeostatic model assessment for insulin resistance (−15.7%, p < 0.001), diastolic blood pressure (−5.6%, p < 0.001), reduced glutathione (+39.8%, p < 0.001), 10-year CVD risk (−17.4%, p = 0.011), and total bilirubin (−21.7%, p < 0.001) compared to baseline. These results suggest that hybrid-type neuromuscular training may improve aspects of cardiometabolic health and antioxidant status in inactive overweight and obese women providing a time-efficient (~100 min/week) exercise approach in a real-world gym setting.

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Section: Antioxidant Capacity Responsessupporting

confidence: 64%

Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial

et al. 2021

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“…Macrophages then stimulate adipokine secretion, including proinflammatory mediators such as Tumor Necroting Factor α (TNF α), Interleukin 1β (IL 1β), and Interleukin 6 (IL 6). Furthermore, adipokine secretion disorders will cause an increase in food intake and a decrease in energy expenditure by the hypothalamus, thereby reducing insulin sensitivity in the skeletal muscle and liver (12)(13)(14)(15). Inflammation and oxidative stress in obesity are the mechanisms underlying the metabolic syndrome as a complication of obesity.…”

Section: Discussionmentioning

confidence: 99%

Fat mass as the main contributor to the Body Mass Index of obese patients in Banyumas Regency

Candrawati

Fatchurohmah

Mustofa

et al. 2021

Proceeding ICMA-SURE

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Body Mass Index (BMI) measurement is the indicator most often used to identify whether a person is obese or not. However, BMI is not always synonymous with body fat mass because many other body components that play a role in determining BMI, such as muscle mass and bone mass. This study aims to determine whether the BMI of obese patients can represent body fat mass. This study was a cross-sectional study. A total of 76 obese women aged 18-34 years were taken by consecutive sampling. The examination of height and weight were performed to determine the BMI. Meanwhile, the measurements of fat mass, muscle mass, and bone mass were carried out using a bioelectric impedance analyzer (BIA). Analysis of data used Pearson correlation test and Multiple Linear Regression analysis. The level of significance was at p<0.05. The results of the Pearson correlation test showed that there was a significant correlation between fat mass, muscle mass, bone mass, and BMI (p=0.000). Multivariate test using Multiple Linear Regression analysis showed that only fat mass has a significant relationship with BMI (p=0.000), R square=0.978, and the regression equation BMI = -2.860+0.807 fat mass. The main contributor to the BMI of obese patients in Banyumas was fat mass. For every 1% increase in fat mass, the BMI will increase by 0.807

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“…Nitrite levels were a reliable measure of nitric oxide and evaluated through the reaction of Griess's reagent with the sample, according to the method described by Miranda and collaborators (2001) (33). Plasma Advanced Oxidation Protein Products (AOPP) were determined spectrophotometrically according to the method previously described by Henke et al (2018) (34). The results were calculated using the standard curve as the chloramine equivalent and are shown as µmol/L.…”

Section: Cell Redox Statementioning

confidence: 99%

Aedes aegypti salivary extracts exert immunomodulatory effects onmacrophages, dendritic cells, and T lymphocytes and increase Zikavirus production in vitro.

Hilario,

Haubert,

Dorneles

et al. 2024

Preprint

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Background This study delves into the complex interplay between Aedes aegypti salivary gland extract and immunological cells during Zika virus (ZIKV) infection. Focusing on key immune cells, including macrophages, dendritic cells, and mononuclear cells from human peripheral blood (PBMCs), it aims to unravel the intricate mechanisms through which mosquito saliva possibly modulates the immunological landscape, influencing ZIKV transmission, host susceptibility, and disease progression. The research sheds light on the role of mosquito saliva in enhancing viral replication and impairing cells involved in host defenses, offering new insights into arbovirus pathogenesis and potential intervention strategies. Methods Using the FIOCRUZ-PE243|2015 ZIKV strain, the research evaluates the Aedes aegypt salivary extracts (SGE's) impact on cytokine production in dendritic and macrophage cell lines, as well as its influence on the redox state and cytokine responses in human PBMCs. Flow cytometry assesses immune cell profiling, aiming to understand SGE's role in ZIKV infectivity and immune modulation. Results SGE enhances pro-inflammatory cytokine production in both dendritic cells and macrophages, while also inducing a Th2 cytokine profile, evidenced by decreased IFN-γ and increased IL-4 levels in PBMCs. Furthermore, SGE exposure leads to increased dendritic cell frequencies, altered T lymphocyte dynamics, and elevated oxidative stress markers. Conclusions It highlights how SGE not only facilitates ZIKV infection by modulating cytokine production and oxidative stress but also alters immune cell dynamics.

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Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

Cited by 6 publications

References 42 publications

Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial

Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial

Fat mass as the main contributor to the Body Mass Index of obese patients in Banyumas Regency

Aedes aegypti salivary extracts exert immunomodulatory effects onmacrophages, dendritic cells, and T lymphocytes and increase Zikavirus production in vitro.

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