Aedes aegypti salivary extracts exert immunomodulatory effects onmacrophages, dendritic cells, and T lymphocytes and increase Zikavirus production in vitro.
Gabriel Hilario,
Alison Haubert,
Gilson Dorneles
et al.
Abstract:Background
This study delves into the complex interplay between Aedes aegypti salivary gland extract and immunological cells during Zika virus (ZIKV) infection. Focusing on key immune cells, including macrophages, dendritic cells, and mononuclear cells from human peripheral blood (PBMCs), it aims to unravel the intricate mechanisms through which mosquito saliva possibly modulates the immunological landscape, influencing ZIKV transmission, host susceptibility, and disease progression. The research sheds light … Show more
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