Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice

Abstract

This study presents the actions of risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by ketamine (Ket) on open-field (OF), rota rod (RR) and tail suspension (TS) tests in mice. Male Swiss albino mice (25-30g) were used. Antipsychotics were administered alone (Risp: 0.1 or 0.2 mg/kg, ip; Hal: 0.1 and 0.2 mg/kg, ip) or thirty minutes before Ket (10 mg/Kg, ip). Ket increased (Ket: 63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by Ket. In RR, Ket decreased (Ket: 15 ± 4.1) the permanence time of the animals compared to control (Control: 59 ± 0.6), but this effect was not observed when neuroleptics were administered alone. Pretreatment with neuroleptics reverted the effect of Ket only in the RR. While Ket (17.3 ± 5.6) decreased the time of immobility in the tail suspension test compared to the control (80.2 ± 10.2), the pretreatment with neuroleptics reverted this mobility. The action of neuroleptics in this model made possible the blockade of the effects caused by acute administration of Ket. Thus, the mechanism of action of ketamine may involve the dopaminergic system.

Morin Pretreatment Attenuates Schizophrenia-Like Behaviors in Experimental Animal Models

“…The rota rod test, as a model for forced motor coordination (an index of extrapyramidal symptom) was carried as described by Arruda et al [33]. The apparatus (Ugo basile, Model57625) consisted of a horizontal metal rod coated with rubber (3 cm diameter) attached to a speed motor.…”

Central Nervous System Activity of Acute Administration of Latex Proteins from Calotropis procera in Mice

“…Haloperidol reduces cortical activation and, consequently, the recruitment and rate modulation of motor units in the spinal cord (Parr-Brownlie, Hyland, 2005). Previous work in our laboratory showed that it was able to block ketamine-induced hyperlocomotion in mice (Arruda et al, 2008).…”

“…Ketamine is a NMDA antagonist that, in acute doses, increases locomotor activity in mice (Arruda et al, 2008;Yamamoto et al, 1997). The mechanism by which ketamine produces hyperlocomotion, at least in part, have been attributed to the blockade of NMDA receptors located on inhibitory GABAergic neurons at limbic and subcortical brain regions, disinhibiting glutamatergic transmission in the prefrontal cortex and ventral tegmental area.…”

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

“…It is well described in the literature that repeated administration of KET is used as an animal model to induce behaviour such as schizophrenia‐like . Since the deficits in PPI and hyper locomotion induced by KET are related to positive‐ and negative‐like symptoms of schizophrenia .…”

“…It is well described in the literature that repeated administration of KET is used as an animal model to induce behaviour such as schizophrenia-like. [3,[31][32][33] Since the deficits in PPI and hyper locomotion induced by KET are related to positive-and negative-like symptoms of schizophrenia. [31,33,34] We can suggest that Eryt reversed these symptoms induced by KET with results comparable to those obtained with olanzapine, an atypical antipsychotic drug widely used in the psychiatric clinic.…”