Active CMOS Sensor Array for Electrochemical Biomolecular Detection

Levine, Peter M.; Gong, Ping; Levicky, Rastislav; Shepard, Kenneth L.

doi:10.1109/jssc.2008.925407

Cited by 179 publications

(130 citation statements)

References 28 publications

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“…Figure 3 shows a schematic representation of the amperometric sensor interface. This interface can be used for carrying out the voltammetry analytical method, which is the representation of the current as a function of the applied potential [7,8]. It has three connections to the sensor electrodes: V WorkAmp , V RefAmp , and V AuxAmp .…”

Section: Potentiostatic Measurementmentioning

confidence: 99%

Intelligent NFC potassium measurement strip with hemolysis check in capillary blood

Kollegger

Greiner

Siegl

et al. 2018

Elektrotech. Inftech.

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130 million people in Western Europe and the USA suffer from chronic cardiac degeneration or kidney insufficiency. The medical treatment requires a routine medical examination accompanied by laboratory blood analyses. This is cost-intensive for the health care system and also time consuming for the patients. This paper presents an economical, wireless sensor node solution in terms of an intelligent near field communication (NFC) potassium measurement strip (NPMS) usable in a home environment. The NPMS comprises two different electrochemical sensors for the acquisition of two parameters in capillary blood and an autonomous sense and identification grain (ASIG) for the electrical analysis, communication, and data transfer. The ASIG is equipped with an integrated amperometric and potentiostatic functionality, radio frequency identification (RFID) interface for high frequency (HF)/NFC, and has been designed using a 130 nm CMOS standard process. It facilitates the implementation of two different measurement techniques, which are necessary for the accurate determination of the potassium concentration in capillary blood, whereby the occurrence of hemolysis can be detected. This NPMS impresses with its large scale integration and is solely powered by the NFC reader device.Keywords: NFC; amperometry; potentiometry; CMOS Intelligenter NFC-Kalium-Messstreifen mit Hämolysekontrolle in Kapillarblut. Mess-und Identifikations-Chip (ASIG) Millionen Menschen in Westeuropa und den USA leider an chronischer Herz-oder Niereninsuffizienz. Die Behandlung erfordert eine regelmäßige medizinische Untersuchung, welche mit Laboranalysen des Blutes einhergeht. Dies ist kostenintensiv für das Gesundheitswesen und auch zeitaufwendig für den Patienten. Dieser Beitrag präsentiert eine ökonomische, drahtlose Sensorknotenlösung in Form eines intelligenten NFC-Kalium-Messstreifens (NPMS) für den Heimgebrauch. Der NPMS enthält zwei verschiedene elektrochemische Sensoren für die Erfassung zweier Parameter im Kapillarblut und einen autonomen

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Section: Potentiostatic Measurementmentioning

confidence: 99%

Intelligent NFC potassium measurement strip with hemolysis check in capillary blood

Kollegger

Greiner

Siegl

et al. 2018

Elektrotech. Inftech.

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“…(12) A biosensor is composed of a working electrode (W), a reference electrode (R), and a counter electrode (C). The working electrode attached with the biomolecular probes can generate the reaction of the target.…”

Section: Principle Of Potentiostat Operationmentioning

confidence: 99%

Design and Implementation of Potentiostat with Standalone Signal Generator for Vanillylmandelic Acid Biosensors

2017

Sensors and Materials

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In this paper, a portable potentiostat with a standalone signal generator is proposed for the signal processing of vanillylmandelic acid (VMA) biosensors. The proposed potentiostat primarily consists of two microprocessors: one is used to design the programmable waveform generator, and the other is used to measure the current of the biosensors. It can perform general electrochemical analysis functions, such as cyclic voltammetry (CV), linear sweep voltammetry (LSV), differential pulse voltammetry (DPV), amperometry (IT), and potentiometry (E). In the experiment, we adopt a VMA biosensor to verify the performance of the proposed potentiostat. The experimental results show that the proposed potentiostat has the merits of good accuracy, larger range of detected sensor current, low cost, and high portability.

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“…Table 5.2 summarized methods and associated costs for reducing the noise. 11,12 and L 17,18 Area and bandwidth…”

Section: Circuit Designmentioning

confidence: 99%

CMOS Analog Front-End IC for Gas Sensors

Kim

Bakkaloglu²

2011

Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT)

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This thesis presents a gas sensor readout IC for amperometric and conductometric electrochemical sensors. The Analog Front-End (AFE) readout circuit enables tracking long term exposure to hazardous gas fumes in diesel and gasoline equipments, which may be correlated to diseases. Thus, the detection and discrimination of gases using microelectronic gas sensor system is required. This thesis describes the research, development, implementation and test of a small and portable based prototype platform for chemical gas sensors to enable a low-power and low noise gas detection system. The AFE reads out the outputs of eight conductometric sensor array and eight amperometric sensor arrays. The IC consists of a low noise potentiostat, and associated 9bit current-steering DAC for sensor stimulus, followed by the first order nested chopped Σ∆ ADC. The conductometric sensor uses a current driven approach for extracting conductance of the sensor depending on gas concentration. The amperometric sensor uses a potentiostat to apply constant voltage to the sensors and an I/V converter to measure current out of the sensor. The core area for the AFE is 2.65x0.95 mm 2 .The proposed system achieves 91 dB SNR at 1.32 mW quiescent power consumption per channel. With digital offset storage and nested chopping, the readout chain achieves 500 µV input referred offset.iii ACKNOWLEDGEMENTS

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Active CMOS Sensor Array for Electrochemical Biomolecular Detection

Cited by 179 publications

References 28 publications

Intelligent NFC potassium measurement strip with hemolysis check in capillary blood

Intelligent NFC potassium measurement strip with hemolysis check in capillary blood

Design and Implementation of Potentiostat with Standalone Signal Generator for Vanillylmandelic Acid Biosensors

CMOS Analog Front-End IC for Gas Sensors

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