“…Therefore, more detailed epidemiological and statistically analysed data is needed before the exact relationship can be confirmed. Nevertheless, irrespective of the histological progression of disease, demyelination is probably the most frequently occurring manifestation of CDE (SILVA et al, 2009;SONNE et al, 2009), and histological manifestations of CDE are more frequently observed within the cerebellum (VANDEVELDE; FANKHAUSER; KRISTENSEN, 1981;JONES;HUNT;KING, 1997;SILVA et al, 2009), followed by the diencephalon, frontal lobe of the telencephalon, pons, and the mesencephalon (SILVA et al, 2009). Demyelination in CDE is considered more severe within the white matter of the cerebellum, rostral medullary velum, optic tracts, spinal cord, and around the fourth ventricle, and might be associated with viral dissemination via the cerebrospinal fluid (CASWELL; WILLIAMS, 2007).…”