Canine distemper virus active infection in order Pilosa, family Myrmecophagidae, species Tamandua tetradactyla

Lunardi, Michele; Darold, Gabriela Molinari; Amude, Alexandre Mendes; Headley, Selwyn Arlington; Sonne, Luciana; Yamauchi, Kelly Cristiane Ito; Boabaid, Fabiana M.; Alfieri, Alice Fernandes

doi:10.1016/j.vetmic.2018.04.030

Cited by 23 publications

(19 citation statements)

References 23 publications

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“…Some studies have also reported CDV infection in other mammalian families, such as Cricetidae (rodents), Cercopithecidae (Old World monkeys), Suidae (pigs), and Elephantidae (elephants) (for a comprehensive review, see [3]). Furthermore, recently CDV was reported as the causative agent of the neurological signs observed on a captive southern tamandua ( Tamandua tetradactyla, family Myrmecophagidae , order Pilosa) in Brazil [27].…”

Section: Disease In Domestic Dogs and Wildlifementioning

confidence: 99%

Evolution and Interspecies Transmission of Canine Distemper Virus—An Outlook of the Diverse Evolutionary Landscapes of a Multi-Host Virus

Duque-Valencia

Sarute

Olarte‐Castillo

et al. 2019

Viruses

118

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Canine distemper virus (CDV) is a worldwide distributed virus which belongs to the genus Morbillivirus within the Paramyxoviridae family. CDV spreads through the lymphatic, epithelial, and nervous systems of domestic dogs and wildlife, in at least six orders and over 20 families of mammals. Due to the high morbidity and mortality rates and broad host range, understanding the epidemiology of CDV is not only important for its control in domestic animals, but also for the development of reliable wildlife conservation strategies. The present review aims to give an outlook of the multiple evolutionary landscapes and factors involved in the transmission of CDV by including epidemiological data from multiple species in urban, wild and peri-urban settings, not only in domestic animal populations but at the wildlife interface. It is clear that different epidemiological scenarios can lead to the presence of CDV in wildlife even in the absence of infection in domestic populations, highlighting the role of CDV in different domestic or wild species without clinical signs of disease mainly acting as reservoirs (peridomestic and mesocarnivores) that are often found in peridomestic habits triggering CDV epidemics. Another scenario is driven by mutations, which generate genetic variation on which random drift and natural selection can act, shaping the genetic structure of CDV populations leading to some fitness compensations between hosts and driving the evolution of specialist and generalist traits in CDV populations. In this scenario, the highly variable protein hemagglutinin (H) determines the cellular and host tropism by binding to signaling lymphocytic activation molecule (SLAM) and nectin-4 receptors of the host; however, the multiple evolutionary events that may have facilitated CDV adaptation to different hosts must be evaluated by complete genome sequencing. This review is focused on the study of CDV interspecies transmission by examining molecular and epidemiological reports based on sequences of the hemagglutinin gene and the growing body of studies of the complete genome; emphasizing the importance of long-term multidisciplinary research that tracks CDV in the presence or absence of clinical signs in wild species, and helping to implement strategies to mitigate the infection. Integrated research incorporating the experience of wildlife managers, behavioral and conservation biologists, veterinarians, virologists, and immunologists (among other scientific areas) and the inclusion of several wild and domestic species is essential for understanding the intricate epidemiological dynamics of CDV in its multiple host infections.

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Section: Disease In Domestic Dogs and Wildlifementioning

confidence: 99%

Evolution and Interspecies Transmission of Canine Distemper Virus—An Outlook of the Diverse Evolutionary Landscapes of a Multi-Host Virus

Duque-Valencia

Sarute

Olarte‐Castillo

et al. 2019

Viruses

118

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“…CDV is a highly contagious virus that can cause fatality in the domestic dog [3,4]. The distemper virus affects a wide range of animal families, both domestic and wild, including Canidae (dog, fox, wolf, raccoon dog), Mustelidae (ferret, mink, skunk, wolverine, martin, badger, otter), Procyonidae (raccoon, coati), Ailuridae (red panda, giant panda), Ursidae (bear), Elephantidae (Asian elephant), some primates (Japanese monkey), Viverridae (civet), Pinnipedia (seals, walrus, sea lion), Felidae (large cats), Myrmecophagidae (Tamandua tetradactyla) commonly known as Southern tamandua, and most recently reported in giant anteater (Myrmecophaga tridactyla) in Brazil [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors of canine distemper virus in the pet and stray dogs in Haa, western Bhutan

Dorji

Tenzin²,

Tenzin³

et al. 2020

BMC Vet Res

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Background: Canine Distemper Virus (CDV) is a highly contagious virus belonging to family Paramyxovirade, genus Morbillivirus and responsible for high morbidity and mortality in dogs worldwide. Infected domestic dogs can cause spillover infections to wild carnivores that are in contact. We conducted a seroprevalence survey of CDV in domestic dogs in two areas of western Bhutan (Haa district) located at the periphery of the Jigme Khesar Strict Nature Reserve, which is home to several endangered wildlife. A total of 238 serum samples, 119 each from the pet and stray dog, were collected during summer and winter seasons. Samples were tested for CDV antibodies using a sandwich enzyme-linked immune-sorbent assay (ELISA) test. Results: The seroprevalence of CDV was found to be 11.3% (95% CI 6.7-14.2). Dogs sampled during winter were less likely to test seropositive against CDV antibodies than those sampled during summer (adjusted odds ratio:-2.6; 95% CI: − 1.2-6.1). Dogs in good body condition were found to be more likely to test seropositive against CDV than dogs in poor condition and obese dogs (adjusted odds ratio: 2.2; 95% CI: 0.1-5.9). There were no significant differences in the seroprevalence of CDV among different sexes, breeds and age classes, pet and stray dogs and between the two study sites. Conclusions: Our study indicates that CDV seroprevalence was equally distributed among pet and stray dogs. We suggest strengthening the management practices of dogs through responsible dog ownership, dog population management and waste management to minimize the transmission risk of infectious diseases to wildlife.

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“…Regarding pathogenesis, protein V is involved in suppressing the innate immune response by inhibiting the induction of type I and II interferons and the activity of the NF-κβ complex by the interaction of the Y110 site with the STAT1 molecules, and the W240-W250 region by the binding to STAT2 [4,5,26]. Protein V also inhibits the Mda5 signaling pathway by binding to the R233-E235 sites [26].…”

Section: Discussionmentioning

confidence: 99%

“…CDV is a negative-sense single-stranded RNA virus, and its genome consists of 15,690 nucleotides that include six genes that code for structural proteins: nucleocapsid (N) (encapsulates viral RNA), phosphoprotein (P) (protein cofactor of the viral polymerase), matrix protein (M) (internal layer of viral envelope), fusion protein (F) (fusion between the viral envelope and the membrane of the host), hemagglutinin (H) (cellular tropism), and the large protein (L) (viral polymerase). The P gene also encodes two nonstructural proteins, proteins C and V, which inhibit the response of type I and II interferons [4,5].…”

Section: Introductionmentioning

confidence: 99%

Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia

2019

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Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection.

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Canine distemper virus active infection in order Pilosa, family Myrmecophagidae, species Tamandua tetradactyla

Cited by 23 publications

References 23 publications

Evolution and Interspecies Transmission of Canine Distemper Virus—An Outlook of the Diverse Evolutionary Landscapes of a Multi-Host Virus

Evolution and Interspecies Transmission of Canine Distemper Virus—An Outlook of the Diverse Evolutionary Landscapes of a Multi-Host Virus

Seroprevalence and risk factors of canine distemper virus in the pet and stray dogs in Haa, western Bhutan

Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia

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