Acetyl- and <i>O</i>-alkyl- derivatives of β-mangostin from <i>Garcinia mangostana</i> and their anti-inflammatory activities

Karunakaran, Thiruventhan; Ee, Gwendoline Cheng Lian; Ismail, Intan Safinar; Nor, Siti Mariam Mohd; Zamakshshari, Nor Hisam

doi:10.1080/14786419.2017.1350666

Cited by 21 publications

(8 citation statements)

References 14 publications

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“…Using a LPS-induced RAW264.7 macrophage model, 3,4,5,6-tetrahydroxyxanthone (4) and mangiferin (7) were found to suppress the generation of TNF-α and intercellular adhesion molecule-1 (ICAM-1) [28]. Six xanthones, including 1,3,6,7-tetrahydroxy-8-prenylxanthone (19) [29], β-mangostin (22) [30], nagostenone F (30) [31], inophinnin (33) [32], garcinoxanghone B (40) [33], and garcinoxanthone C (41) [33], were reported to reduce NO production in LPS-stimulated RAW264.7 macrophage. 6'-O-acetyl mangiferin (OAM) (8), an acetylated xanthone C-glucoside, was reported to suppress iNOS and COX-2 expression, thereby inhibiting the levels of TNF-α, IL-1β, and IL-6 in LPS-stimulated RAW264.7 cells.…”

Section: Xanthones With Anti-inflammatory Propertiesmentioning

confidence: 99%

Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis

Feng

Gan

et al. 2020

Molecules

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Inflammation is the body’s self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases. Current therapeutic approaches include mainly non-steroidal anti-inflammatory drugs and glucocorticoids, which are generally of limited effectiveness and severe side-effects. Thus, it is urgent to develop novel effective anti-inflammatory therapeutic agents. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo. Herein, we provide a comprehensive and up-to-date review of xanthones with anti-inflammatory properties, and analyzed their drug likeness, which might be potential therapeutic agents to fight against inflammation-related diseases.

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Section: Xanthones With Anti-inflammatory Propertiesmentioning

confidence: 99%

Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis

Feng

Gan

et al. 2020

Molecules

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“…Buravlev et al (2018) modified α-and γ-mangostin through Mannich reactions (aminomethylated at the C-4/C-5 positions) which consequently led to higher anti-oxidant activities than their original compounds. Furthermore, Karunakaran et al (2018) showed that β-mangostin could inhibit the inflammatory response in lipopolysaccharide-induced RAW 264.7 macrophages, but this activity was not retained when the hydroxyl (OH) group at its position C-6 was replaced with acetyl or alkyl. These lines of evidence highlight the importance of certain functional groups in xanthones to confer their bioactivities including anti-oxidant and anti-inflammation.…”

Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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“…Buravlev et al (2018) modified α-and γmangostin through Mannich reactions (aminomethylated at the C-4/C-5 positions) which consequently led to higher anti-oxidant activities than their original compounds. Furthermore, Karunakaran et al (2018) showed that β-mangostin could inhibit the inflammatory response in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, but this activity was not retained when the hydroxyl (OH) group at its position C-6 was replaced with acetyl or alkyl. These lines PeerJ reviewing PDF | (2018:09:30985:1:1:NEW 30 Nov 2018)…”

Section: Metabolite Composition Of Mangosteenmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities

Cited by 21 publications

References 14 publications

Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis

Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

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