Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Abstract

Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

“…Local people used various parts of Garcinia mangostana Linn. for treatment of diarrhea, wound infection, and fevers (14). Extensive pharmacological activities of mangosteen and its active compounds have been identified in many studies previously.…”

“…Extensive pharmacological activities of mangosteen and its active compounds have been identified in many studies previously. The effects include anticancer, antibacterial, and antimalarial, as well as for the treatment of Alzheimer's disease (14,15).…”

Garcinia mangostana L. Clusiaceae

“…It is commonly sold in supermarkets and local markets of Southeast Asia (Franco et al 2020). Several food uses were reported by Aizat et al (2019b) such as food products (dried aril, fruit jam, peel drink, yogurt, ice cream, chocolate, and lozenges), animal feed (dairy steer, lactating cows, broiler chicken), and food shell life (spoilage detection and fruit anti-browning).…”

“…G. garcinia is also one of Garcinia species. A comprehensive review from Aizat et al (2019b) showed that G. mangostana offers a multitude of economic benefits ranging from technological and biomedical applications to advanced industrial materials. Products derived from G. mangostana are expected to benefit various biomaterial or biomedical industries and local communities, particularly farmers, traders, and consumers worldwide.…”

Cytotoxic Effects of Mangosteen Pericarp Extracts on Oral Cancer and Cervical Cancer Cells

“…The pericarp of mangosteen is rich in bioactive agents, such as xanthones, flavonoids, procyanidin, and benzophenones, which are said to contribute to its anti-inflammatory, antibacterial, and anticancer effects (Aizat et al, 2018). The percentage of xanthones is high in the pericarp rather than the pulp of the fruit (Sukatta et al, 2013).…”