Abnormal spontaneous brain activity in type 2 diabetes with and without microangiopathy revealed by regional homogeneity

Peng, Juan; Qu, Hang; Peng, Jing; Luo, Tianyou; Lv, Fajin; chen, Li; Wang, Zhuo-Nan; Ouyang, Yu; Cheng, Qingfeng

doi:10.1016/j.ejrad.2015.12.024

Cited by 53 publications

(63 citation statements)

References 29 publications

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“…Cui et al (2014) studied the effects of glycemic variability at distinct time scales and found that subjects with greater glycemic variability both had less gray matter within the limbic system and exhibited worse cognitive performance. Many previous studies have also found that T2DM patients show abnormal spontaneous brain activity in these brain regions of the limbic system, based on assessments of the amplitude of low frequency fluctuations or regional homogeneity (Zhou et al, 2014; Peng et al, 2016). One study using voxel-based analysis found that patients with T2DM showed abnormal mean diffusivity in the left parahippocampus (Hsu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

Liu

Wang

et al. 2017

Front. Aging Neurosci.

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Background and Purpose: Previous studies of voxel-based morphometry (VBM) have found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter alterations, but these findings are inconsistent and have not been quantitatively reviewed. Therefore, the aim of this study was to conduct a quantitative meta-analysis of VBM studies of patients with T2DM.Materials and Methods: The seed-based d mapping method was applied to quantitatively estimate the regional gray matter abnormalities in T2DM patients. We also used meta-regression to explore the effects of some demographics and clinical characteristics.Results: Seven studies, with 8 datasets comprising 530 participants with T2DM and 549 non-T2DM controls, were included. The pooled and subgroup meta-analyses found that T2DM patients showed robustly reduced gray matter in the bilateral superior temporal gyrus, middle temporal gyrus, medial superior frontal gyrus, insula, median cingulate cortex, precuneus cortex and the left lentiform nucleus extending into the parahippocampus. The meta-regression also found that the percentage of female patients with T2DM was negatively associated with gray matter in the right superior temporal gyrus and illness duration was negatively associated with gray matter in the right middle temporal gyrus.Conclusion: This meta-analysis indicates that T2DM patients have significantly and robustly reduced gray matter mainly in the cortical-striatal-limbic networks, which are associated with human cognition. Thereby implicating this finding in the pathophysiology of cognitive impairment in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

Liu

Wang

et al. 2017

Front. Aging Neurosci.

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“…The results of Oikawa et al [68] suggest similar changes within the bone marrow-localized blood vessels in type 1 diabetes mellitus (T1DM). Recently, Peng et al [69] characterized bone microstructure, strength, and the course of bone turnover in a study performed on streptozotocin (STZ)-induced diabetic mice (T1D mice). The authors also explored the role of angiogenesis in the pathogenesis of T1D-induced osteoporosis.…”

Section: Dysfunction Of Bone Blood Vessels In Skeletal and Systemic Dmentioning

confidence: 99%

“…The study revealed a decreased angiogenesis (i.e., reduced number of blood vessels in the femur and decreased expression of platelet endothelial cell adhesion molecule (CD31), NGF-nerve growth factor, the previously mentioned HIF-1α and VEGF) in type 1 diabetic mice compared to their healthy counterparts. Peng et al [69] concluded that the impairment of angiogenesis is the main cause of a decreased bone formation and imbalanced remodeling, observed in diabetes. A report recently published by Portal-Núñez et al [70] indicates an important role of aging in worsening the bone-related complications associated with diabetes mellitus.…”

Section: Dysfunction Of Bone Blood Vessels In Skeletal and Systemic Dmentioning

confidence: 99%

The role of vasculature in bone development, regeneration and proper systemic functioning

et al. 2017

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Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients, hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is indispensable for appropriate bone development, regeneration and remodeling. Bone vasculature also orchestrates the process of hematopoiesis. Blood supply to the skeletal system is provided by the networks of arteries and arterioles, having distinct molecular characteristics and localizations within the bone structures. Blood vessels of the bone develop through the process of angiogenesis, taking place through different, bone-specific mechanisms. Impaired functioning of the bone blood vessels may be associated with the occurrence of some skeletal and systemic diseases, i.e., osteonecrosis, osteoporosis, atherosclerosis or diabetes mellitus. When a disease or trauma-related large bone defects appear, bone grafting or bone tissue engineering-based strategies are required. However, a successful bone regeneration in both approaches largely depends on a proper blood supply. In this paper, we review the most recent data on the functions, molecular characteristics and significance of the bone blood vessels, with a particular emphasis on the role of angiogenesis and blood vessel functioning in bone development and regeneration, as well as the consequences of its impairment in the course of different skeletal and systemic diseases.

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“…Recently, researchers have focused on the T2DM-related brain function alteration at resting state. For example, the altered spontaneous brain activity in multiple brain regions has been revealed by both low-frequency fluctuations (ALFF; Xia et al, 2013; Cui et al, 2014; Wang C. X. et al, 2014; Zhou et al, 2014) and regional homogeneity (ReHo) studies (Cui et al, 2014; Peng et al, 2016) on T2DM patients. The ALFF and ReHo analysis are two most important methods to describe the characteristics of rsfMRI signals in the brain.…”

Section: Introductionmentioning

confidence: 99%

Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus

Liu

Yang

et al. 2017

Front. Neurosci.

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Type 2 diabetes mellitus (T2DM) is related to cognitive impairments and increased risk for dementia. Neuroimaging studies have demonstrated T2DM-related brain structural and functional changes which are partly associated to the cognitive decline. However, few studies focused on the early neuroimaging findingsin T2DM patients. In this study, a data-driven whole-brain resting state functional connectivity strength (rsFCS) methodwas used to evaluate resting functional changes in 53 T2DM patients compared with 55 matched healthy controls (HCs), and to detect the associations between the rsFCSchanges and cognitive functions in T2DM patients. The T2DM patients exhibited weaker long-range rsFCS in the right insula and weaker short-range rsFCS in the right supramarginalgyrus (SG) compared with the HCs. Additionally, seed-based functional connectivity (FC) analysis revealed weaker FC between the right insula and the bilateral superior parietal lobule (SPL), and between the right SG and the bilateral supplementary motor area (SMA)/right SPL in T2DM patientscompared with the HCs. In T2DM patients, negative correlation was found between the long-range rsFCS in the right insula and HbA1c levels; and the FC between the right SG and the bilateral SMA negatively correlated with TMT-A scores. Our results indicated that the rsFCS alteration occurredbefore obvious cognitive deficits in T2DM patients, which might be helpful for understanding the neuromechanism of cognitive declines in T2DM patients.

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Abnormal spontaneous brain activity in type 2 diabetes with and without microangiopathy revealed by regional homogeneity

Cited by 53 publications

References 29 publications

Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

The role of vasculature in bone development, regeneration and proper systemic functioning

Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus

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