Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

Liu, Jia; Wang, Wenhui; Ma, Liuhong; Ma, Xiaoyue; Shi, Shaojie; Gong, Qiyong; Wang, Meiyun

doi:10.3389/fnagi.2017.00161

Cited by 44 publications

(46 citation statements)

References 41 publications

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“…The finding on brain tissue density change is consistent with previous studies that showed reduced regional gray matter in brain sites such as prefrontal cortex, medial temporal, anterior cingulate, and medical frontal lobes, and hippocampal region in T2DM patients as compared with non-T2DM control subjects. 18,20,31 Etiology of the brain damage specifically occurring in prefrontal cortices in T2DM is not fully understood. However, diabetic vasculopathy (arterial stiffness, atherosclerosis, and endothelial dysfunction) and oxidative stress are believed to be important potential underlying mechanisms of T2DM-induced brain injury by causing neuroinflammation, neurodegeneration, and neuronal apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

Choi

Roy

Freeby

et al. 2020

Journal of Diabetes

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Background: This study examined brain tissue integrity in sites that controls cognition (prefrontal cortices; PFC) and its relationships to glycemic outcomes in adults with type 2 diabetes mellitus (T2DM). Methods: We examined 28 T2DM patients (median age 57.1 years; median body mass index [BMI] 30.6 kg/m 2 ;11 males) and 47 healthy controls (median age 55.0 years; median BMI 25.8 kg/m 2 ; 29 males) for cognition (Montreal Cognitive Assessment [MoCA]), glycemic control (hemoglobin A1c [HbA1c]), and PFC tissue status via brain magnetic resonance imaging (MRI). High-resolution T1-weighted images were collected using a 3.0-Tesla MRI scanner, and PFC tissue changes (tissue density) were examined with voxel-based morphometry procedures. Results: Reduced PFC density values were observed in T2DM patients compared to controls (left, 0.41 ± 0.02 mm 3 /voxel vs 0.44 ± 0.02 mm 3 /voxel, P < 0.001; right, 0.41 ± 0.03 mm 3 /voxel vs 0.45 ± 0.02 mm 3 /voxel, P < 0.001).PFC density values were positively correlated with cognition; left PFC region (r = 0.53, P = 0.005) and right PFC region (r = 0.56, P = 0.003), with age and sex as covariates. Significant negative correlations were found between PFC densities and HbA1c values; left PFC region (r = −0.39, P = 0.049) and right PFC region (r = −0.48, P = 0.01), with age and sex as covariates. Conclusions: T2DM patients showed PFC brain tissue damage, which is asso-

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Section: Discussionmentioning

confidence: 99%

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

Choi

Roy

Freeby

et al. 2020

Journal of Diabetes

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“…The checklist was made in accordance with the studies published before (12,19). The contents of the checklist were included in the Table S1.…”

Section: Quality Assessmentmentioning

confidence: 99%

Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus

et al. 2020

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Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted. Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics. Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations. Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.

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“…The DMN is involved in cognitive functions such as episodic memory retrieval, self-referencing, and emotion management (Buckner et al, 2008). Previous studies have found decreased gray-matter volume in DMN-related regions (Liu et al, 2017), and abnormal FC within the DMN as well as between the DMN and other brain regions (including the cerebellum) in patients with T2DM (Zhou et al, 2010;Musen et al, 2012;Zhang et al, 2015;Yang et al, 2016). The present study provides further evidence for the impairment of the cerebellumcerebral DMN connection in patients with T2DM, especially a disconnection between the bilateral cerebellar region IX and the right cuneus/precuneus.…”

Section: Decreased Connectivity Of the Cerebellum-cerebral Dmn In T2dmmentioning

confidence: 99%

Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus

Zhang

Gao

et al. 2020

Front. Neurosci.

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The role of the cerebellum in type 2 diabetes mellitus (T2DM) has been receiving increased attention. However, the functional connectivity (FC) between the cerebellar subregions and the cerebral cortex has not been investigated in T2DM. Therefore, the purpose of this study was to investigate cerebellar-cerebral FC and the relationship between FC and clinical/cognitive variables in patients with T2DM. A total of 34 patients with T2DM and 30 healthy controls were recruited for this study to receive a neuropsychological assessment and undergo resting-state FC. We selected four subregions of the cerebellum (bilateral lobules IX, right and left Crus I/II, and left lobule VI) as regions of interest (ROIs) to examine the differences in cerebellar-cerebral circuits in patients with T2DM compared to healthy controls. Correlation analysis was performed to examine the relationship between FC and clinical/cognitive variables in the patients. Compared to healthy controls, patients with T2DM showed significantly decreased cerebellar-cerebral FC in the default-mode network (DMN), executive control network (ECN), and visuospatial network (VSN). In the T2DM group, the FC between the left cerebellar lobule VI and the right precuneus was negatively correlated with the Trail Making Test A (TMT-A) score (r = −0.430, P = 0.013), after a Bonferroni correction. In conclusion, patients with T2DM have altered FC between the cerebellar subregions and the cerebral networks involved in cognitive and emotional processing. This suggests that a range of cerebellar-cerebral circuits may be involved in the neuropathology of T2DM cognitive dysfunction.

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Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

Cited by 44 publications

References 41 publications

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus

Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus

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