Abnormal adsorption and desorption behavior of pharmaceutical drugs on polystyrene microspheres

Wang, Teng; Zheng, Yuhua; Wang, Xiaoting; Wang, Qiang; Ke, Cong‐Yu; Austin, Daniel E.; Han, Xiaoxiao; Zhang, Zhiping

doi:10.1039/c7ra01693j

Cited by 5 publications

(3 citation statements)

References 75 publications

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“…Specifically, a higher sensitivity in paper spray analysis would be achieved when PS particles with a stronger adsorption interaction were used as coating material, which is evident in Figure and Figures S3 and S4. Extensive study revealed that neither the high voltage and the paper substrate nor the adhesive agent had significant impact on the desorption behavior . Our hypothesis is that this phenomenon might originate from the unique desorption behavior of therapeutic drugs from the surface of PS-coated paper substrates.…”

Section: Resultsmentioning

confidence: 85%

“…In a recent study, we found that when PS was used as a material for coating paper substrates, the stronger the adsorption interaction between PS particles and therapeutic drugs, the larger possible signal and better sensitivity of those drugs from PS particle coated paper spray. Specifically, a higher sensitivity in paper spray analysis would be achieved when PS particles with a stronger adsorption interaction were used as coating material, which is evident in Figure and Figures S3 and S4.…”

Section: Resultsmentioning

confidence: 99%

“…Extensive study revealed that neither the high voltage and the paper substrate nor the adhesive agent had significant impact on the desorption behavior. 58 Our hypothesis is that this phenomenon might originate from the unique desorption behavior of therapeutic drugs from the surface of PS-coated paper substrates.…”

Section: Analytical Chemistrymentioning

confidence: 97%

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Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

et al. 2017

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Polystyrene (PS) is a class of polymer materials that offers great potential for various applications. However, the applications of PS microspheres in paper spray mass spectrometry are largely underexplored. Herein we prepared a series of PS microspheres via a simple dispersion polymerization and then used them as coating materials for paper spray mass spectrometry (MS) in high-sensitivity analysis of various therapeutic drugs in complex biological matrixes. In the preparation of PS-coated papers, the coating method was found playing a key role in determining the performance of the resulting paper substrate in addition to other parameters (e.g., starch type and amount, PS coating amount, and spray solvent). We also found that as a solvent was applied on PS-coated paper for paper spray, the analytes of interest would be first extracted out and then moved to the tip of paper triangle for spray along with the applied solvent. In the process, the surface energy of PS particles had a strong impact on the desorption performance of analytes from PS-coated paper substrate, and the PS with a high surface energy favored the elution of analytes to allow a high MS sensitivity. When the prepared PS coated paper was used as a substrate for paper spray, it gave high sensitivity in analysis of therapeutic drugs in various biological matrixes such as whole blood, serum, and urine with excellent repeatability and reproducibility. In contrast to uncoated filter paper, an improvement of 10-546-fold in sensitivity was achieved using PS-coated paper for paper spray, and an estimated lower limit of quantitation (LLOQs) in the range of 0.004-0.084 ng mL was obtained. The present study is significant in exploring the potential of PS for high-sensitivity MS analysis, and it provides a promising platform in the translation of the MS technique to clinical applications.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

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Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

et al. 2017

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A strip test for the optical determination of influenza virus H3 subtype using gold nanoparticle coated polystyrene latex microspheres

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Comparison of six digestion methods on fluorescent intensity and morphology of the fluorescent polystyrene beads

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Abnormal adsorption and desorption behavior of pharmaceutical drugs on polystyrene microspheres

Abstract: We report an abnormal adsorption and desorption behavior where a stronger adsorption interaction between polystyrene particles and pharmaceutical drugs results in preferable desorption behavior.

Cited by 5 publications

References 75 publications

Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

A strip test for the optical determination of influenza virus H3 subtype using gold nanoparticle coated polystyrene latex microspheres

Comparison of six digestion methods on fluorescent intensity and morphology of the fluorescent polystyrene beads

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