Ability of Rat to Adapt to Stress of Light Restraint.

Production of Gastric Hemorrhage in Rats by Multiple Stresses

“…Restraint, starvation, environmental changes and drugs have all been shown to produce gastric ulcers in rats in 24 hours (1)(2)(3). Studies on combinations of these factors indicated stressors synergized in their effects, since exposure of rats to restraint and starvation produced a higher incidence of gastric lesions than either stress alone ( 4 ) , while restraint and cold stress were synergistic as stressors in production of hypothermia in rats (5). This report concerns a study of the effect of a combination of stressors (cold and restraint in starved rats), in an attempt to produce gastric lesions rapidly, and a study of the mechanism by which the stomach was damaged.…”