Age differences in the body temperature response to restraint-cold stress

Paré, William P.

doi:10.1016/0031-9384(89)90178-9

Cited by 9 publications

(1 citation statement)

References 18 publications

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“…In most of these studies 'young' animals have been in the range of 12-44 weeks with 'old' considered as 96 weeks or over [ 12] (against this background our 'old' rats cannot be considered as 'aged'; perhaps it would be more propitious to refer to them as 'young' and 'older'!). Old rats were less able to respond to a mild cold chal lenge, and oxygen consumption and rectal temperature declined from 12 to 96 weeks of age, with a stable period between 24 and 36 weeks [13]; the significantly lower resting Tc at a Ta of 25 °C noted in the old rats in the present study is in agreement with this re port.…”

Section: Discussionmentioning

confidence: 99%

Cocaine and Body Temperature in the Rat: Effects of Exercise and Age

Lomax¹,

Daniel²

1990

Pharmacology

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The laboratory rat is being used to determine if abuse of cocaine is a risk factor in the pathogenesis of exercise-induced heatstroke. The effect of running on a treadmill on the core temperature (T_c) has been studied in two groups of rats: animals ≈20 weeks old (‘young rats’) and animals « 52 weeks old (‘old rats’). During 60 min running the T_cincreased to a steady level, within 15–30 min, which was higher in the old than in the young animals at environmental temperatures (T_a) of 25 and 30 °C. A significantly greater rise occurred in both groups of animals at T_a of 30 compared to 25 °C. Injection of cocaine (20 mg/kg) was without effect on the rise in T_c in young animals running at a T_a of 25 °C but significantly increased the hyperthermia in the old rats. It is suggested that the rise in the thermoregulatory set point induced by muscle exercise is greater with advancing age. Also in older animals, the effect of cocaine on the central nervous system may be enhanced.

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Section: Discussionmentioning

confidence: 99%