Abdominal obesity and other components of metabolic syndrome among the young population of Novosibirsk

Ragino, Yu. I.; Oblaukhova, V. I.; Денисова, Д. В.; Kovalkova, N A

doi:10.29001/2073-8552-2020-35-1-167-176

Cited by 3 publications

(1 citation statement)

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“…и соавт. на большей выборке, которые явились прогностически неблагоприятными в отношении кардиоваскулярной патологии среди молодых женщин г. Новосибирска [17].…”

Section: обсуждение основного результата исследованияunclassified

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

et al. 2021

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Background: Hyperprolactinemia is one of the most common hypothalamic-pituitary-endocrine disorders in women of reproductive age, with the highest frequency at the age of 25–44 years. In addition to influencing the reproductive system, it is important to study the effects of prolactin (PRL) on various metabolic links. Available data indicate that the effect of PRL on metabolism depends on its level. In this regard, the study of the relationship of different levels of PRL with anthropometric parameters, indicators of lipid and carbohydrate metabolism in young women is relevant.Aim: To study the frequency of metabolic syndrome (MS) and its individual components in women aged 25–45 years with different levels of prolactin.Materials and methods: Work design — cross-sectional research. A randompopulationsample of women 25–45 agedwas examined. Pregnant and breastfeeding women with macroprolactinoma, and taking antipsychotics were excluded. Information was collected using a structured questionnaire, including, but not limited to, the presence of pregnancies, childbirth, menstrual irregularities, and a clinical examination, anthropometric measurements, biochemical and hormonal blood analyzes were performed. Statistical data processing was carried out.Results: According to the inclusion and exclusion criteria, this analysis presents data from 401 women, the average age of the examibed was 36.14±6.19 years. There was no difference in the levels of thyroid-stimulating hormone and prolactin (PRL) in the age groups of 25–34 and 35–45 years. According to the survey, the incidence of thyroid diseases in the studied groups is comparable. Every fifth woman indicated menstrual irregularities. Among women 25–45 years old, women with low-normal PRL values (Me = 4.49 [3.52; 5.41] ng/ml) have more unfavorable metabolic indicators. Metabolic syndrome (MS) was detected in 28%,with a predominant increase in the frequency of abdominal obesity — 55%, hypercholesterolemic LDL — 63%. Women with high PRL (Me = 41.35 [34.78; 45.88] ng / ml) also have an unfavorable metabolic profile: MS was detected in 47%, abdominal obesity — 56%, hypertension — 39%.Conclusions: In women 25–45 years old, low and high PRL values are more often associated with metabolic ill health. PRL values are from 7.8 to 28 ng / ml, i.e. conditionally defined as normal, highly normal and at the level of moderate hyperprolactinemia contribute to the maintenance of a favorable metabolic profile. When deciding on the treatment of women with non-tumor etiology hyperprolactinemia, it is important to assess the metabolic status, expanding their understanding of PRL as a hormone associated only with lactation and with the pituitary-gonad axis.

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Section: обсуждение основного результата исследованияunclassified

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

et al. 2021

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Some Aspects of Epidemiology and Etiopathogenesis of Metabolic Syndrome

Abdullozoda¹

2020

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A review of literature data carried out on the most important aspects of epidemiology, risk factors and pathogenesis of metabolic syndrome (MS). Metabolic syndrome has been found in approximately one quarter of the world’s population, and, despite the large-scale treatment, preventive and health-improving promotion programs on a global scale, the number of persons with MS tends to increase annually, especially among young ablebodied age. There are many risk factors in its genesis, including genetic predisposition, low physical activity, poor diet, smoking, intestinal microbiota, obstructive sleep apnea syndrome and others, the role of most of which needs to be studied in more depth. Many criteria have been proposed for the diagnosis of MS, each of them has its own advantages and disadvantages. With MS, most organs and systems are affected, and with the combined involvement of the cardiovascular, endocrine, urinary, digestive and respiratory systems burdened clinical course of MS. In connection with the above, there is a reason for further scientific research to identify the causes and risk factors for the development of MS, development of preventive ways of prevention, preventive diagnostics and early treatment of MS. Keywords: metabolic syndrome, epidemiology, pathogenesis, diabetes mellitus, insulin resistance, obesity, hypercholesterolemia.

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Association of pro-atherogenic risk factors with thyroid-stimulating hormone level in women 25–44 years old

Alferova,

Mustafina,

Rymar

et al. 2024

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Thyroid hormones play an important role in regulating metabolism. A large body of literature suggests an increased risk of developing metabolic syndrome (MS) in individuals with hypothyroidism, but little data exists on the effects of high-normal levels of thyroid-stimulating hormone (TSH) on metabolism.Material and methods. The study was conducted on a representative sample of people aged 25–44 years (n = 1513, of which 840 were women). The analysis included the results of 343 women. A questionnaire, anthropometric and biochemical study were carried out. Biochemical parameters were analyzed in quartiles of TSH content. Determination of MS was carried out using the criteria of NCEP ATP III (2001), IDF (2005), VNOK (2009).Results. TSH content in the examined sample was 1.5 [1.0; 2.2] mU/l (median [lower quartile; upper quartile]). Among women 25–44 years old, women with highly normal TSH level (3.1 [2.7, 3.8] mU/l) have less favorable metabolic parameters. MS was detected in 31 % cases, with a predominant increase in the frequency of abdominal obesity – in 51 %, with increased triglyceride levels in 18 %. Women with hypertriglyceridemia had higher TSH content than those with normal triglyceride levels (2.4 ± 1.6 vs. 1.8 ± 1.3 mU/L, respectively, p = 0.007).Conclusions. In women 25–44 years of age, high-normal TSH content is more often associated with metabolic unhealth.

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Abdominal obesity and other components of metabolic syndrome among the young population of Novosibirsk

Cited by 3 publications

References 20 publications

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

Some Aspects of Epidemiology and Etiopathogenesis of Metabolic Syndrome

Association of pro-atherogenic risk factors with thyroid-stimulating hormone level in women 25–44 years old

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