A systematic review of dental disease in patients undergoing cancer therapy

Abstract

IntroductionThis purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies.Review methodA systematic literature search was conducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental caries, severe gingival disease, and dental infection. Data on DMFT/dmft, DMFS/dmfs, plaque, and gingival indexes were also gathered. The level of evidence, recommendation, and guideline (if possible) were given for published preventive and management strategies.ResultsSixty-four published papers between 1990 and 2008 were reviewed. The weighted overall prevalence of dental caries was 28.1%. The overall DMFT for patients who were post-antineoplastic therapy was 9.19 (SD, 7.98; n = 457). The overall plaque index for patients who were post-antineoplastic therapy was 1.38 (SD, 0.25; n = 189). The GI for patients who were post-chemotherapy was 1.02 (SD, 0.15; n = 162). The weighted prevalence of dental infections/abscess during chemotherapy was reported in three studies and was 5.8%.ConclusionsPatients who were post-radiotherapy had the highest DMFT. The use of fluoride products and chlorhexidine rinses are beneficial in patients who are post-radiotherapy. There continues to be lack of clinical studies on the extent and severity of dental disease that are associated with infectious complications during cancer therapy.

Oral complications of cancer and cancer therapy

“…2), and osteoradionecrosis (ORN). 119 Preventive measures are critical to minimize adverse long-term dental outcomes (Table 9). Underlying risk factors for poor dental outcome should be identified and addressed prior to initiating therapy.…”

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

“…As saliva and tear fluid have lubricating and protective functions, reduced flow rates lead to remarkably increased risk of oral and eye infections, including generalized dental caries, periodontitis, fungal infections and conjunctivitis. [4][5][6][7] In addition, subjective symptoms of dry mouth (xerostomia), altered taste/vision, eating and speaking problems and sensation of a foreign body in the eye are common and known to have a significant impact on the QoL. 8 In a recent study, objectively determined hyposalivation was found in B50% of patients 6 months post-HSCT.…”

Radyoterapi ve kemoterapi görmüş hastanın diş üstü protezle rehabilitasyonu: olgu bildirimi

“…Protez yapımı için doğru zamana, ancak radyografik ve klinik incelemeyle karar verilmelidir. [7][8][9][10] Pow ve ark. 7 nazofarenks kanseri tedavisi görmüş 109 hastaya protez uygulamış-lardır.…”