2013
DOI: 10.1038/bmt.2012.260
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Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Abstract: The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and th… Show more

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Cited by 22 publications
(32 citation statements)
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“…Although oral cGvHD is mild in the majority of patients, it should always be considered as clinically significant due to its often prolonged duration. In a subset of patients it is a continuous source of pain, impairing oral function, affecting alimentation and nutritional status, impeding the maintenance of oral health, and reducing quality of life [82, 83]. In a cohort of RIC HSCT recipients, cGvHD-related oral symptoms developed with a median onset of seven months after transplant persisted for a median duration of six months and reoccurred in one-third of affected patients [79].…”
Section: Graft Versus Host Diseasementioning
confidence: 99%
“…Although oral cGvHD is mild in the majority of patients, it should always be considered as clinically significant due to its often prolonged duration. In a subset of patients it is a continuous source of pain, impairing oral function, affecting alimentation and nutritional status, impeding the maintenance of oral health, and reducing quality of life [82, 83]. In a cohort of RIC HSCT recipients, cGvHD-related oral symptoms developed with a median onset of seven months after transplant persisted for a median duration of six months and reoccurred in one-third of affected patients [79].…”
Section: Graft Versus Host Diseasementioning
confidence: 99%
“…Side effects and disorders of the oral cavity are common and can be found in approximately 80% of the HSCT recipients. Of these, hyposalivation is particularly frequent and may be one of the fundamental factors in the pathogenesis of oral disorders post‐HSCT . Over time, hyposalivation and changes in salivary composition and oral biofilms almost inevitably cause dental caries, periodontitis and mucosal infections .…”
Section: Introductionmentioning
confidence: 99%
“…3,4,7 HSCT recipients are predisposed to infectious diseases, and the quality of life can be reduced throughout the lifetime. 4,[7][8][9][10] Thus, prevention and treatment of these comorbidities are of increasing clinical importance and essential for supportive care.…”
mentioning
confidence: 99%
“…13 Oral cGVHD involvement is associated with diminished oral health-related QOL, but the impact of oral or other organ-specific involvement on global QOL measures is unclear. 14,15,16,17 The objective of this study was to characterize the impact of oral cGVHD on global measures of QOL after alloHSCT.…”
Section: Introductionmentioning
confidence: 99%