Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler, Thomas; Mauramo, Matti; Rovó, Alicia; Stangel, Martin; Halter, Joerg; Buser, Andreas; Tyndall, Alan; Häusermann, Peter; Gratwohl, Aloïs; Thewis, André; Brennan, Michael T.; Waltimo, Tuomas

doi:10.1038/bmt.2012.260

Cited by 21 publications

(28 citation statements)

References 39 publications

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“…Although oral cGvHD is mild in the majority of patients, it should always be considered as clinically significant due to its often prolonged duration. In a subset of patients it is a continuous source of pain, impairing oral function, affecting alimentation and nutritional status, impeding the maintenance of oral health, and reducing quality of life [82, 83]. In a cohort of RIC HSCT recipients, cGvHD-related oral symptoms developed with a median onset of seven months after transplant persisted for a median duration of six months and reoccurred in one-third of affected patients [79].…”

Section: Graft Versus Host Diseasementioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.

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Section: Graft Versus Host Diseasementioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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“…Side effects and disorders of the oral cavity are common and can be found in approximately 80% of the HSCT recipients. Of these, hyposalivation is particularly frequent and may be one of the fundamental factors in the pathogenesis of oral disorders post‐HSCT . Over time, hyposalivation and changes in salivary composition and oral biofilms almost inevitably cause dental caries, periodontitis and mucosal infections .…”

Section: Introductionmentioning

confidence: 99%

“…3,4,7 HSCT recipients are predisposed to infectious diseases, and the quality of life can be reduced throughout the lifetime. 4,[7][8][9][10] Thus, prevention and treatment of these comorbidities are of increasing clinical importance and essential for supportive care.…”

mentioning

confidence: 99%

Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Uutela

Passweg

Gerull

et al. 2019

European J of Haematology

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Objectives Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. Methods Two hundred and sixty nine adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with 6‐month survival and the progression of the oral disorders within 2 years were examined. Results Forty HSCT recipients (14.8%) deceased within 6 months post‐HSCT. Among the deceased recipients, hyposalivation and caries were more common pre‐HSCT than in recipients who survived over 6 months (P < 0.05). HSCT recipients with hyposalivation pre‐HSCT had higher risk of death (HR: 1.90, 95% CI:1.00‐3.60; P = 0.044) within 6 months post‐HSCT compared with recipients without hyposalivation. Hyposalivation pre‐HSCT was associated with a higher DMFT index score (P < 0.05) and a smaller number of teeth (P < 0.005) 24 months post‐HSCT in comparison with those without hyposalivation. Conclusions Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post‐HSCT.

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“…13 Oral cGVHD involvement is associated with diminished oral health-related QOL, but the impact of oral or other organ-specific involvement on global QOL measures is unclear. 14,15,16,17 The objective of this study was to characterize the impact of oral cGVHD on global measures of QOL after alloHSCT.…”

Section: Introductionmentioning

confidence: 99%

Assessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life

et al. 2015

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Chronic GVHD (cGVHD) is a frequent complication of allogeneic hematopoietic stem cell transplantation (HSCT) and affects multiple organ systems, with the oral cavity being one of the most frequently affected sites. Patients with cGVHD experience reduced quality of life (QOL), yet the specific impact of oral cGVHD on QOL is poorly understood. OBJECTIVE The objective of this study was to characterize the impact of oral cGVHD on global measures of QOL. METHODS QOL data were collected using the FACT-BMT and SF-36 instruments for 569 patients enrolled in the Chronic GVHD Consortium, with a total of 1,915 follow-up visits. At study enrollment, patients were categorized as isolated oral cGVHD (n=22), oral and concomitant extra-oral cGVHD (n=420), and only extra-oral cGVHD (n=127). Utilizing all longitudinal data, QOL scores were compared using a multivariable linear model controlling for demographic, transplant, and cGVHD characteristics. RESULTS Patients with isolated oral cGVHD reported better physical well-being (P=0.009), BMT well-being (P=0.01), and decreased bodily pain (P=0.01) compared to patients with oral and concomitant extra-oral cGVHD, but the differences in scores did not reach the defined threshold for clinical significance (6 points for FACT-BMT domains and 5 points for SF-36 domains). CONCLUSIONS Global QOL scores are similar in patients with isolated oral cGVHD and patients with oral and concomitant extra-oral cGVHD.

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Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Cited by 21 publications

References 39 publications

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Assessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life

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