A simple route to fluids with photo-switchable viscosities based on a reversible transition between vesicles and wormlike micelles

Oh, Hyun‐Taek; Ketner, Aimee M.; Heymann, Romina R.; Kesselman, Ellina; Danino, Dganit; Falvey, Daniel E.; Raghavan, Srinivasa R.

doi:10.1039/c3sm00070b

Cited by 76 publications

(70 citation statements)

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“…Many of these aggregates, long worm-like micelles, dense vesicles, etc., may entangle with each other or densely arrange to form a gel-like system [53][54][55][56][57][58]. Surfactants can also form fibrillar crystalline gels which are mostly in compounded systems [59,60], which have many advantages.…”

Section: Introductionmentioning

confidence: 98%

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Wang

Hao

2013

Colloid Polym Sci

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New hydrogels having high water content, ∼96 wt%, composed of cationic surfactants, alkyltrimethylammonium bromides (C n TAB, n=12,14,16,and 18), and a small dye molecule, sodium azobzenzene 4,4′-dicarboxylic acid (AzoNa 2 ), was firstly obtained. The three-dimensional network structures of hydrogels were determined by transmission electron microscopy images, scanning electron microscopy images, 1 H nuclear magnetic resonance, and small-angle X-ray scattering measurements. The mechanism of hydrogel formation was also illustrated. The rheological data were obtained to investigate the mechanical strength of hydrogels, which were turned out to be strong mechanical strength (∼10 4 Pa) materials. We found that the strength of the hydrogel depends on the fiber density, which can be controlled by changing the proportion of the two compounds, concentration of surfactants, temperature, and the chain length of the surfactant. Interestingly, the hydrogels were found to have a multiple-stimulus response property. A reversible thermal, UVvis, or a chemical response was investigated in the mixtures of cationic surfactants and azoic salt for the first time. These findings may find potential applications such as sensors, actuators, shape memories, and drug delivery systems, etc.

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Section: Introductionmentioning

confidence: 98%

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Wang

Hao

2013

Colloid Polym Sci

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“…are being developed. Ever since the first report of synthetic vesicles derived from as imple organic molecule by Kunitake et al in late 70'so ft he last century, [17] there have been abundance of examples of synthetic vesicles derived from organic molecules, [18][19][20][21][22] that are actively being pursued as potential drug delivery vehicles. [23] However,t here are obvious impediments (e.g.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Zn^II‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery

Bera

Chowdhury

Dastidar

2020

Chemistry An Asian Journal

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A series of coordination polymers synthesized from a bis‐pyridyl linker, namely 4,4′‐azopyridine (L), selected non‐steroidal‐anti‐inflammatory drugs (NSAIDs), namely diclofenac (Dic), ibuprofen (Ibu), flurbiprofen (Flu), mefenamic acid (Mefe), and naproxen (Nap), and Zn(NO3)2 were characterized by single crystal X‐ray diffraction. One of the coordination polymers, namely CP3 derived from Flu, was able to form metallovesicles in DMSO, DMSO/H2O and DMSO/DMEM (biological media) as revealed by TEM, AFM and DLS. Metallovesicle formation by CP3 was further supported by loading a fluorescent dye, namely calcein, as well as an anti‐cancer drug, doxorubicin hydrochloride (DOX), as revealed by UV‐vis and emission spectra, and fluorescence microscopy. DOX‐loaded metallovesicles of CP3 (DOX@CP3‐vesicle) could be delivered in vitro to a highly aggressive human breast cancer cell line, namely MDA‐MB‐231, as revealed by MTT and cell migration assays, and also cell imaging performed under laser scanning confocal microscope (LSCM). Thus, a proof of concept for developing a multi‐drug delivery system derived from a metallovesicle for delivering an anti‐cancer drug to cancer cells is demonstrated for the first time.

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“…As a result, SWLMs have attracted considerable attention in applications ranging from cosmetics, drag reducing agents to drug delivery systems . SWLMs can be tuned to desired applications by a variety of environmental triggers like pH, CO 2, light, and temperature . Amongst these triggers, pH has been reported as a facile and economical way to control such micellar assemblies and hence their bulk properties .…”

Section: Introductionmentioning

confidence: 99%

A Green pH‐switchable Amino Acid Based Smart Wormlike Micellar System for Efficient and Controlled Drug Delivery

et al. 2017

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A biocompatible and biodegradable amino‐acid based anionic surfactant system has been formulated which self assembles into wormlike micelles in presence of NaCl and displays excellent sol‐gel transition under pH stimulus. The surfactant synthesized was Sodiumtetradecanoyl Phenyl Alanine (STDPA). The micellar solution behaves as sol at /below pH 8.25 and transforms into gel at /above pH 8.65, exhibiting sol‐gel transition in a very narrow pH range. This pH triggered sol‐gel transition shows excellent reversibility upon recurrent changes in pH. Steady and dynamic rheological experiments reveal that the solution at/above pH 8.65 is viscoelastic due to the formation of wormlike micelles (WLMs) and was Newtonian at/below 8.25 due to the presence of spherical micelles. The microstructural evolution was further validated by Dynamic Light Scattering and Cryo TEM imaging. Further, the formulation was used to study the release of drug Ibuprofen (IBU) at these two pHs. IBU release from the material depends on pH of the release medium and occurs without any burst release at pH 8.65.

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A simple route to fluids with photo-switchable viscosities based on a reversible transition between vesicles and wormlike micelles

Cited by 76 publications

References 50 publications

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Design and Synthesis of Zn^II‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery

A Green pH‐switchable Amino Acid Based Smart Wormlike Micellar System for Efficient and Controlled Drug Delivery

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A simple route to fluids with photo-switchable viscosities based on a reversible transition between vesicles and wormlike micelles

Cited by 76 publications

References 50 publications

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures

Design and Synthesis of ZnII‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery

A Green pH‐switchable Amino Acid Based Smart Wormlike Micellar System for Efficient and Controlled Drug Delivery

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Design and Synthesis of Zn^II‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery