A sarcoidosis patient with hand involvement and large pulmonary lymph nodes: results of 1-year treatment with methotrexate

Alemdaroğlu, Ebru; Ertürk, Arzu; Eroğlu, Ayşe Gürler

doi:10.1007/s10067-010-1487-2

Cited by 6 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sarcoidosis or Besnier-Boeck-Schaumann syndrome, is an idiopathic multisystem inflammatory disease characterized by non-caseating granulomas primarily involving the lungs and mediastinal lymph nodes. Musculoskeletal involvements such as sarcoid arthropathy and myopathy were reported in up to 10% of patients [ 1 ]. It is associated with chronic, prolonged disease course.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic contracture of the hands in sarcoid myopathy

2023

View full text Add to dashboard Cite

Hand involvement in sarcoidosis is rare and it presents as tenosynovitis, dactylitis, nodules and osteoarticular bony destruction. We describe an unusual presentation of progressive intrinsic muscle contracture of both hands in a 42-year-old woman with sarcoid myopathy who presented with painful swelling and weakness of all four extremities. Her systemic symptoms improved with oral corticosteroids, but the hand muscle contracture remained after resolution of myositis. Serial soft tissue releases of intrinsic muscle contracture improved hand function markedly. This case highlights that surgery is a viable option to treat intrinsic muscle contracture in patients with chronic sarcoid myopathy complicated with severe muscle contracture.

show abstract

Section: Introductionmentioning

confidence: 99%

Intrinsic contracture of the hands in sarcoid myopathy

2023

View full text Add to dashboard Cite

show abstract

“…The work on the study of immunosuppressants in the treatment of patients with respiratory sarcoidosis is few, only one randomized study of the effectiveness of methotrexate in a small group of patients (24 patients) was conducted [9,10]. Experts of the World Association of Sarcoidosis and other Granulomatous Lesions (WASOG) analyzed literature data on the effectiveness of methotrexate in limited series of observations and developed general recommendations for its use [11,12].…”

Section: Introductionmentioning

confidence: 99%

Efficiency and Safety of Leflunomide Treatment in Patients With Pulmonary Sarcoidosis

Gavrysiuk¹,

Merenkova²,

Гуменюк

2018

EUREKA: Health Sciences

View full text Add to dashboard Cite

Patients who have contraindications to the prescription of GCs (glucocorticosteroids), or have developed serious side effects during treatment with GCs, as well as patients with resistance to GCs therapy, are prescribed immunosuppressants. The aim of the research - to study the efficacy of leflunomide monotherapy in patients with pulmonary sarcoidosis with contraindications to prescription or serious side effects of glucocorticosteroids. Fourteen patients with sarcoidosis of the respiratory system of stage II were examined – 12 women and 2 men aged 30 to 69 years. In 10 patients there were contraindications to the appointment of GCs (diabetes mellitus – 5, hypertension – 3, obesity – 1, exacerbation of gastric ulcer – 1), which caused the appointment of immunosuppressive therapy as a starting. In 4 cases, serious side effects of SCs were noted, requiring the drug to be abolished (osteoporosis – 3, steroid diabetes – 1). Leflunomide was administered at a dose of 20 mg per day, daily for 3 months. The evaluation of efficacy was carried out using computed tomography of the thoracic cavity organs, body plethysmography, spirometry and determination of the diffusivity of the lungs. Monotherapy with leflunomide in patients with contraindications to prescription or serious side effects of GCs was successful in 7 out of 13 patients, in 2 patients there was a stabilization of the process, in 4 patients with leflunomide therapy progression of the disease was noted and in 1 case the treatment was discontinued due to serious side effects of preparation. The results obtained make it possible to recommend the use of leflunomide as monotherapy in patients with pulmonary sarcoidosis with contraindications to the prescription and/or poor tolerability of GCs and methotrexate. It is necessary to continue studying the possibilities of combined use of leflunomide with other drugs of the first line.

show abstract

The clinical importance of the thyroid nodules during anti-tumor necrosis factor therapy in patients with axial spondyloarthritis

et al. 2017

View full text Add to dashboard Cite

The clinical importance of the thyroid nodules in patients with axial spondyloarthritis (ax-SpA) rests with the need to exclude thyroid malignancy. The aim of this study is to assess the risk of thyroid malignancy in ax-SpA patients receiving anti-TNF therapy. From September 2015 until December 2015, 70 patients diagnosed with ax-SpA were included in the research. Forty of the patients had received anti-TNF therapy, and 30 of the patients were anti-TNF naive. All cases were screened for the presence of nodules in the thyroid gland with ultrasound. Of the patients that received anti-TNF therapy, 15 (37.5%); and of the anti-TNF naive patients, 11 (36.7%) had thyroid nodule(s). Four patients from the anti-TNF group underwent fine needle aspiration biopsy of the nodules, and two of them were diagnosed with papillary thyroid carcinoma. None of the nodules in anti-TNF naive patients required biopsy. When compared to the normal population, the standardized incidence ratio (SIR) was found to be increased in both male (SIR 2.03, 95% CI 1.9 to 18) and female (SIR 2.7, 95% CI 2.6 to 24) cases. It is not yet established whether the development of cancer during the treatment process is the effect of the treatment or if it is a part of the natural course of the disease or if it is coincidental. We saw a mild increase in thyroid malignancies in ax-SpA patients who received anti-TNF therapy. Therefore, we believe that the thyroid gland should also be taken into consideration while screening for malignancy before anti-TNF therapy.

show abstract

A sarcoidosis patient with hand involvement and large pulmonary lymph nodes: results of 1-year treatment with methotrexate

Abstract: Sarcoidosis infrequently involves the phalanges and the adjacent soft tissue. The management of bone lesions is not clear. We present herein the results of methotrexate therapy applied for 1 year in a sarcoidosis patient with hand involvement and large hilar lymphadenopathies.

Cited by 6 publications

References 6 publications

Intrinsic contracture of the hands in sarcoid myopathy

Intrinsic contracture of the hands in sarcoid myopathy

Efficiency and Safety of Leflunomide Treatment in Patients With Pulmonary Sarcoidosis

The clinical importance of the thyroid nodules during anti-tumor necrosis factor therapy in patients with axial spondyloarthritis

Contact Info

Product

Resources

About