The clinical importance of the thyroid nodules during anti-tumor necrosis factor therapy in patients with axial spondyloarthritis

Terlemez, Rana; Akgün, Kenan; Palamar, Deniz; Boz, Sinan; Sarı, Hidayet

doi:10.1007/s10067-017-3607-8

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Terlemez et al, Yan et al and Liu et al proved that miRNAs affects the phenotype of FLS in rheumatism by regulating the expression of PI3K/AKT, thereby affecting the pathogenesis of rheumatism. [24][25][26] Therefore, we speculate that there may be a regulatory relationship between circRNA_0003307 and the PI3K/AKT pathway.…”

Section: Discussionmentioning

confidence: 93%

Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway

Fang¹,

Liu²,

Long³

et al. 2022

Adv Clin Exp Med

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Background. Ankylosing spondylitis (AS) has a high disability rate, and an early diagnosis is difficult. Objectives.To explore the possible functions and underlying mechanism of circular RNAs Homo sapiens (hsa)_circ_0003307 in ankylosing spondylitis. Materials and methods.The hsa_circ_0003307 expression levels were investigated in the peripheral blood mononuclear cells (PBMCs) of 30 AS patients and 30 healthy controls (HC) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. Primary fibroblast-like synoviocytes (FLS) were separated from synovial tissues, established as cell lines and cultured for subsequent cell experiments involving transfection with different vectors. The qRT-PCR analysis was used for evaluating the levels of hsa_circ_0003307 in AS-FLS. Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway-related protein levels were measured using western blotting and immunofluorescence. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of inflammatory cytokines. Spearman's correlation analysis was used to assess the correlation between hsa_circ_0003307 and clinical characteristics.Results. The expression level of hsa_circ_0003307 was significantly high in AS patients and was positively associated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Bath Ankylosing Spondylitis Functional Index (BASFI). We found that hsa_circ_0003307 overexpression could promote the activation of the PI3K/AKT pathway and expression of inflammatory cytokines -tumor necrosis factor alpha (TNF-α) and TNF-α-induced protein 2 (TNFAIP2). However, hsa_circ_0003307 knockdown reduced the expression of TNF-α and TNFAIP2.Conclusions. The expression level of hsa_circ_0003307 was associated with inflammatory response, and it was revealed that hsa_circ_0003307 knockdown could reduce the inflammatory response of AS by regulating the PI3K/AKT pathway.

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Section: Discussionmentioning

confidence: 93%

Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway

Fang¹,

Liu²,

Long³

et al. 2022

Adv Clin Exp Med

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“…About 37.5% of TNF inhibitor-treated patients had thyroid nodules; however, none of them revealed a malignant transformation. [ 22 ] In a small study, any type of thyroid dysfunction defined according to thyroid stimulating hormone and thyroxine values was found in 27.5% of SpA patients. [ 23 ] Hypothyroidism requiring hormone replacement therapy was found to a lesser extent than other autoimmune rheumatic diseases in SpA patients.…”

Section: Discussionmentioning

confidence: 99%

Real-life data on the comorbidities in spondyloarthritis from our multicenter nationwide registry: BioStar

Çay,

Alkan Melikoğlu,

Gül Yurdakul

et al. 2022

Arch Rheumatol

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Objectives: Considering that the comorbid situations during the management of Spondyloarthritis (SpA) have been underlined in several recommendations, the main objective of this study was to evaluate the comorbid conditions of Turkish patients with SpA. Patients and methods: This cross-sectional observational study was conducted with 1,242 SpA patients (844 males, 398 females; mean age: 43.9±11.0 years; range, 19 to 81 years) diagnosed according to the modified New York criteria for ankylosing spondylitis or the Assessment of SpondyloArthritis International Society (ASAS) criteria. The patient data were collected from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStar) between February 1, 2019, and December 29, 2020. Clinical and demographic data, including, age, sex, disease duration, body mass index (BMI), pain, patient’s global assessment, physician’s global assessment, Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, and Maastricht Enthesitis Score, were recorded. Comorbid conditions were recorded by filling out a questionnaire according to the clinical history or medical records. Charlson Comorbidity Index and Rheumatic Disease Comorbidity Index scores were calculated from the gathered comorbidity information. Results: Nine hundred thirteen patients had radiographic axial SpA, 153 had nonradiographic axial SpA, and 176 had peripheral SpA. The most common comorbidities were hypertension (HT) (n=167, 13.4%), diabetes mellitus (DM) (n=83, 6.7%), thyroid disorders (n=64, 5.6%), and depression (n=61, 4.9%). The comorbidities and the calculated comorbidity indices were significantly higher in females, in those with a BMI >25 kg/m2 , and those over 60 years of age. No relationship was found between smoking and alcohol use and comorbidities. A significantly higher prevalence of HT and DM in peripheral SpA patients and a lower prevalence of thyroid disorders in radiographic axial SpA patients were observed. Conclusion: The most commonly reported comorbidities were HT, DM, thyroid disorders, and depression in SpA patients according to the BioStar database. The frequency of comorbidities and composite comorbidity scores were higher among females, older (>60 years) patients, and overweight (BMI >25 kg/m2 ) patients.

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“…Anti‐TNF‐ α therapy may also contribute to other thyroid diseases, such as Graves' disease, Hashimoto's thyroiditis, amyloid goiter, and papillary thyroid carcinoma . Allanore et al .…”

Section: Discussionmentioning

confidence: 99%

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

2018

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CaseA 41-year-old woman has a 26-year history of psoriasis vulgaris and psoriatic arthritis (PsA). Initially, multiple erythematous to brownish thick scaly plaques and papules were observed over her limbs (Fig. 1). Subsequently, arthralgia developed bilaterally over the knees and progressed to the hands and feet. X-ray films revealed subluxation and deformity of the small hand joints (Fig. 2). Her past medical history was otherwise unremarkable.She received topical steroid, calcipotriol, and broadband ultraviolet B therapy, but the disease persisted with intermittent flare-ups. Methotrexate was prescribed, but active arthritis over the hands, elbows, and right ankle were persistent, hence rheumatologists switched to leflunomide for PsA treatment. Nevertheless, the progression of joint deformities and swelling continued. She was subsequently shifted to adalimumab subcutaneous injection (40 mg every other week).However, she experienced an intermittent cough for 7 months after adalimumab initiation. Three weeks after discontinuation of adalimumab, episodic fever up to 38°C with an intermittent sore throat occurred for 1 week. Subsequently, the symptoms worsened with anterior neck tenderness, low-grade fever, and submandibular lymphadenopathy in the next week.Restless hand tremors and palpitations were also observed.Laboratory data showed thyroid-stimulating hormone (TSH), 0.006 mU/l; T 3 , 3.9 nmol/l; T 4 , >308.9 nmol/l; free T 4 , 52.6 pmol/l; and erythrocyte sedimentation rate, 89 mm/h. The results of a serology survey for influenza infection were Figure 1 Multiple erythematous to brownish thick scaly plaques and papules over the patient's upper limbs ª

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The clinical importance of the thyroid nodules during anti-tumor necrosis factor therapy in patients with axial spondyloarthritis

Cited by 6 publications

References 23 publications

Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway

Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway

Real-life data on the comorbidities in spondyloarthritis from our multicenter nationwide registry: BioStar

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

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