A sandwich-type electrochemical immunosensor based on multiple signal amplification for α-fetoprotein labeled by platinum hybrid multiwalled carbon nanotubes adhered copper oxide

Jiang, Liping; Han, Jian; Li, Faying; Gao, Jian; Li, Yueyun; Dong, Yunhui; Wei, Qin

doi:10.1016/j.electacta.2015.02.050

Cited by 76 publications

(34 citation statements)

References 38 publications

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“…A novel and ultrasensitive sandwich‐type electrochemical immunosensor was also designed for the quantitative detection of AFP using platinum hybrid multiwalled carbon nanotubes adhered copper oxide (Pt@CuO‐MWCNTs) as labels, β‐cyclodextrin functionalized graphene (CD‐GS) as the platform by Li et al. . In their study, Pt, CuO and MWCNTs were utilized as catalysts, which can accelerate the decomposition of H 2 O 2 .…”

Section: Carbon Nanotube Used In Labelsmentioning

confidence: 99%

“…On the other hand, CNTs, an ideal nanomaterial, have been widely incorporated into the fabrication of novel electrochemical immunosensors due to its unique properties, such as free‐standing structure, low background noise, low cost, high stability, and impressive electrical conductivity, a large edge plane/basal plane ratio, rapid electrode kinetics and excellent biocompatibility . Especially, its conductivity plays an important role in enhancing the performance of CNTs in electrochemical immunoassay.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances of Carbon Nanotubes‐based Electrochemical Immunosensors for the Detection of Protein Cancer Biomarkers

2016

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Section: Carbon Nanotube Used In Labelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances of Carbon Nanotubes‐based Electrochemical Immunosensors for the Detection of Protein Cancer Biomarkers

2016

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“…[1][2][3][4][5][6][7][8][9] All these applications require the synthesis of the vital structure of CNT-nanohybrid material without compromising the integrity of the underlying CNT framework. They possess the excellent properties of high surface area, high electrical conductivity, good chemical stability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Controllable gold nanoparticle deposition on carbon nanotubes and their application in immunosensing

et al. 2015

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A CNT-AuNPs hybrid nanocomposite platform was prepared from nanodisperse AuNPs in N- [3-(trimethoxysilyl)propyl]ethylenediamine (EDAS) sol-gel matrices with purified MWCNT. EDAS, an amine group-containing sol-gel solution, was utilized for its ability to stabilize the nanoparticles in solution. The developed model system was based on immobilized rabbit anti-mouse IgG-HRP (horseradish peroxidase) for reagentless detection of mouse IgG. The immunosensing platform was prepared by using Nafion for the immobilization of rabbit anti-mouse IgG-HRP and CNT-AuNPs hybrid nanocomposite on a glassy carbon electrode used for the detection of mouse IgG which provides a biocompatible microenvironment. The resulting CNT-AuNPs nanocomposite brings new capabilities for electrochemical devices by using the synergistic action of its electrocatalytic activity. The CNT-AuNPs were characterized using SEM, TEM, EIS, and AFM, and the analytical performance was monitored by differential pulse voltammetry. The detection limit of mouse IgG is 0.5 ng mL À1 (S/N ratio ¼ 3). In addition, the immunosensor efficiently allowed a specific electrochemical analysis of mouse IgG and easy discrimination of goat IgG, chicken IgG, and rabbit IgG.

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“…In addition, electrochemical immunoassay, based on the principle of specic binding of antibody and antigen, 6,7 has been developed for the detection of diseases for clinical diagnosis. 14,15 Nanomaterials as the biomarkers could improve the performance of markers and enhance the sensitivity of chemical analysis. 8,9 Meanwhile, this technique has been widely applied in product safety, 10 environmental detection, 11 clinical medicine, 12,13 etc.…”

Section: Introductionmentioning

confidence: 99%

An electrochemical immunosensor for ultrasensitive detection of HBsAg based on platinum nanoparticles loaded on natural montmorillonite

Tian

Jia

et al. 2015

Anal. Methods

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A sensitive and facile electrochemical immunosensor for ultrasensitive detection of hepatitis B surface antigen (HBsAg) was designed, which was based on platinum nanoparticle decorated amino silane functionalized montmorillonite (Pt-NH 2 -MMT). As it is a luminosilicate clay mineral, the advantages of montmorillonite (MMT), such as a large specific surface area, good adsorption/ion exchange capacity and innocuousness, endow Pt-NH 2 -MMT with better sensing performance. The platinum nanoparticles (Pt NPs) also play an important role due to their good biological compatibility, electron transport rate and catalytic activity. Pt NPs and the available amine group of second HBsAg-antibody could be bound strongly to each other. And the covalent bond between NH 2 -MMT and the carboxyl group of primary HBsAg-antibody could be formed by the activation of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/ N-hydroxysuccinimide. Under optimal conditions, the Pt-NH 2 -MMT showed high electrocatalytic activity toward hydrogen peroxide reduction. Under optimal conditions, the immunosensor showed a wide linear response to HBsAg ranging from 0.5 pg mL À1 to 20 ng mL À1 with a low detection limit of 2.0 Â 10 À4 ng mL À1 . The designed immunosensor displayed high sensitivity, stability and reproducibility for the analysis of HBsAg.

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A sandwich-type electrochemical immunosensor based on multiple signal amplification for α-fetoprotein labeled by platinum hybrid multiwalled carbon nanotubes adhered copper oxide

Cited by 76 publications

References 38 publications

Recent Advances of Carbon Nanotubes‐based Electrochemical Immunosensors for the Detection of Protein Cancer Biomarkers

Recent Advances of Carbon Nanotubes‐based Electrochemical Immunosensors for the Detection of Protein Cancer Biomarkers

Controllable gold nanoparticle deposition on carbon nanotubes and their application in immunosensing

An electrochemical immunosensor for ultrasensitive detection of HBsAg based on platinum nanoparticles loaded on natural montmorillonite

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