A Role for 3D Printing in Kidney-on-a-Chip Platforms

Sochol, Ryan D.; Gupta, Navin; Bonventre, Joseph V.

doi:10.1007/s40472-016-0085-x

Cited by 41 publications

(15 citation statements)

References 96 publications

(129 reference statements)

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“…Liver failure can be acute and/or chronic, and it can occur due to many reasons; common causes are the ingestion of a toxic substance, medicine, drug overdose, alcohol con- The source of renal cells can be from porcine [156,157], canine [158] or human renal cells [153][154][155]. More recently, 3D printing technologies were applied to mimic a more kidney-like structure [159] in combination with the microfluidic technology [160]. On the other hand, wearable artificial kidney (WAK) devices are actively being developed to improve the quality of life of the patients while reducing the financial burden of long-term treatments [161][162][163].…”

Section: Artificial Livermentioning

confidence: 99%

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

Nguyen

Thi

et al. 2021

Membranes

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The recent outbreak of the COVID-19 pandemic in 2020 reasserted the necessity of artificial lung membrane technology to treat patients with acute lung failure. In addition, the aging world population inevitably leads to higher demand for better artificial organ (AO) devices. Membrane technology is the central component in many of the AO devices including lung, kidney, liver and pancreas. Although AO technology has improved significantly in the past few decades, the quality of life of organ failure patients is still poor and the technology must be improved further. Most of the current AO literature focuses on the treatment and the clinical use of AO, while the research on the membrane development aspect of AO is relatively scarce. One of the speculated reasons is the wide interdisciplinary spectrum of AO technology, ranging from biotechnology to polymer chemistry and process engineering. In this review, in order to facilitate the membrane aspects of the AO research, the roles of membrane technology in the AO devices, along with the current challenges, are summarized. This review shows that there is a clear need for better membranes in terms of biocompatibility, permselectivity, module design, and process configuration.

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Section: Artificial Livermentioning

confidence: 99%

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

Nguyen

Thi

et al. 2021

Membranes

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“…Для биологических применений -таких, как микроваскулярные микроанатомические работы -в 3D-принтированных чипах часто используют гидрогелевые слои , делая акцент на биосовместимость чипов Credi et al, 2018). Биоструктуры на чипе поддерживаются разного уровня сложности -от временной фиксации (цитратный буфер, гепарин или альтернативные -в зависимости от потребностей) клеток крови (Plevniak et al, 2016), сосудистых элементов и процессов васкуляризации в гидрогелях либо анализа гематологических барьеров на чипе (Harding et al, 2017), что сложно, но принципиально очевидно, до культур клеток и органов на чипе Podwin et al, 2018;Miller, 2013): например, от почек (Sochol et al, 2016) до нервной системы , включая девинатные формы и структуры, в частности -онкологические . Одной из задач данных работ является клеточный и тканевый скрининг для фармакологии и токсикологии (Zhan-ying et al, 2014;Tourlomousis et al, 2014).…”

Section: методыunclassified

“MALDI-FLIP-on-a-chip” and “MALDI-FRAP-on-a-flap”: Novel Techniques for Soil Microbiology and Environmental Biogeochemistry. II – Polymer Chip Prototyping (Invited Paper)

2018

Biogeosystem Technique

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In the second part of the article cycle «"MALDI-FLIP-on-a-chip" and "MALDI-FRAP-on-aflap": Novel Techniques for Soil Microbiology and Environmental Biogeochemistry» the polymer chip prototyping techniques are described. In particular, the compatibility problems are discussed. The problem of the biocompatibility of polymer chip surface is eliminated using GIM-surfaced chip exposition in the high-humidity experimental media, which may be interpreted as a model of soils. The problem of compatibilities of fluorescence techniques and polymer chips is resolved (as a part of the general chip optics problem) using microscopic investigations of polymer chip transparency in some different textural variances and microfluorimetric measurements of fluorescent dyes in the chip geometry. The problem of the soil chip prototyping is solved using 3D-printing based on some biocompatible and, so possible, biodegradable polymers. The basic complexity of experimental data is provided in the tables placed in the general article text. Is it possible to create multiparametric analytical technique for synchronous biocompatible soil microbiome analysis and monitoring? It is a general question for the real time environmental control. We can say "Yes", but only if we have a minimal prerequisite case, which we have a good polymer, real "real time" analyzer, biocompatible and biodegradable coatings etc. In other cases the general problem of soil chip design is not a problem of engineering, but it is a problem of soil-chip interface chemical physics and physical chemistry. Such problem may be interpreted only as a principal physical, but not as a technical problem. This part of our article cycle is very simple and sensible, because such problems are not very strong and complexible, consequently, we can take only illustration of principle, but not a full verification and validation of fine and thin mechanisms of soil microbiome interactions with adhesive chip etc. Cureent opinions in soil biology are good compartible with our results, therefor we must not take full theoretical considerations in frames of the current concept paradigm in soil biology. De facto, it is a brief methodical and technical note before the closing of our projects in Russian Federation. It is not a normal research article, because all normal articles may be writed only in normal material and technical conditions.

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“…A nephron-on-a-chip would therefore be a promising tool for the future, perhaps with the help of 3-D bioprinting to enable the precise distribution of cells in a spatially controlled manner. [103][104][105] Lung-on-a-chip…”

Section: Kidney-on-a-chipmentioning

confidence: 99%

Organs-on-a-chip

Bovard

Iskandar

Luettich

et al. 2017

Toxicology Research and Application

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In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D) architecture, which enables interactions between cells, promoting their differentiation and increasing their in vivo likeness. Microengineering now enables the incorporation of small devices into 3-D culture models to reproduce the complex microenvironment of the modeled organ, often referred to as organs-on-a-chip (OoCs). This review describes various OoCs developed to mimic liver, brain, kidney, and lung tissues. Current challenges encountered in attempts to recreate the in vivo environment are described, as well as some examples of OoCs. Finally, attention is given to the ongoing evolution of OoCs with the aim of solving one of the major limitations in that they can only represent a single organ. Multi-organ-on-achip (MOC) systems mimic organ interactions observed in the human body and aim to provide the features of compound uptake, metabolism, and excretion, while simultaneously allowing for insights into biological effects. MOCs might therefore represent a new paradigm in drug development, providing a better understanding of dose responses and mechanisms of toxicity, enabling the detection of drug resistance and supporting the evaluation of pharmacokineticpharmacodynamics parameters.

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A Role for 3D Printing in Kidney-on-a-Chip Platforms

Cited by 41 publications

References 96 publications

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

“MALDI-FLIP-on-a-chip” and “MALDI-FRAP-on-a-flap”: Novel Techniques for Soil Microbiology and Environmental Biogeochemistry. II – Polymer Chip Prototyping (Invited Paper)

Organs-on-a-chip

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