A Review on Woodfordia fruticosa Kurz (Dhatki): Ayurvedic, Folk and Modern Uses

Thakur, Shifali; Kaurav, Hemlata; Chaudhary, Gitika

doi:10.22270/jddt.v11i3.4839

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Though several conventional medications in the form of various formulations acting through different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far away from ideal category especially because of their low safety, limited biological efficacy, adverse effects, chronic and dose dependent toxicities and tendency to produce drug resistance [16]. Thus the current scenario advocates a need for novel agents with higher cardioprotective efficacy with minimal adverse effects and drug interactions [17,18].…”

Section: Discussionmentioning

confidence: 99%

Antiatherosclerotic Activity of Methanolic Extract of Woodfordia fructicosa Flowers

Dharashive¹,

Ghiware²

2022

JPRI

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In the present investigation the methanolic extract of Woodfordia fructicosa flowers at the doses of 100, 200 and 400 mg/kg was investigated for antiatherosclerotic against high fat diet induced atherosclerosis and triton induced atherosclerosis. In high fat diet induced atherosclerosis several parameters of lipid profile such as total cholesterol (TC) and triglycerides (TG), lipoprotein profile such as low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and high density lipoprotein cholesterol (HDLc), atherosclerotic markers such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) and atherogenic index parameters such as TC/HDLc, LDLc/HDLc were determined and found to significantly altered in induction control group treated with high fat diet. The histopathological studies of liver and heart tissue were also performed wherein high fat diet showed toxic effects on cardiac and hepatic tissue. Similarly, in triton induced atherosclerosis parameters of lipid profile such as total cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein levels were determined and were found to be significantly increased in induction control group. methanolic extract of Woodfordia fructicosa flowers showed protection against the atherosclerosis by bringing back the altered parameters to normal I both the models and showing ameliorating effects against high fat diet induced hepatic and cardiac damage. The multistep putative action of methanolic extract of flowers of Woodfordia fructicosa is attributed to the prominent phytoconstituents namely ellagic acid estimated through HPTLC analysis of the extract. Thus the study exhibited the protective effect of methanolic extract of flowers of Woodfordia fructicosa against atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Antiatherosclerotic Activity of Methanolic Extract of Woodfordia fructicosa Flowers

Dharashive¹,

Ghiware²

2022

JPRI

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“…20 Randia dumetorum is such an indigenous medicinal plant which is traditionally claimed to be useful in the treatment of cardiovascular diseases but haven't yet been adequately documented, hence its cardioprotective activity was evaluated against doxorubicin induced cardiotoxicity. 21 The traditional claim, scientific observations and presence of phytochemicals have close relationship towards the actual therapeutic outcome. 22,11 In light of this, the preliminary phytochemical analysis of ethanolic extracts of fruits of Randia dumetorum was carried out.…”

Section: Determination Of Heart Weight Body Weight and Heart Weight T...mentioning

confidence: 99%

Cardioprotective Actvity of Randia Dumetorum against Doxorubicin Induced Cardotoxicity

Dharashive¹,

Ghiware²

2022

Biosci., Biotech. Res. Asia

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In the present investigation the cardioprotective activity of ethanolic extract of Randia dumetorum fruits at the doses of 100, 200 and 400 mg/kg was investigated against doxorubicin induced cardiotoxicity model. In high fat diet induced atherosclerosis several heamodynamic parameters such as systolic and diastolic blood pressure, serum parameters such as lactate dehydrogenase (LDH), tissue parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), and malonaldehyde (MDA) were determined and found to be significantly altered in induction control group treated with doxorubicin. The histopathological studies of cardiac tissue were also performed wherein doxorubicin showed toxic effects on tissue. Ethanolic extract of Randia dumetorum fruits showed protection against doxorubicin induced cardiotoxicity by normalizing the altered parameters and producing ameliorating effects against doxorubicin induced cardiac damage. The multistep putative action of ethanolic extract of Randia dumetorum fruits may be attributed to the prominent phytoconstituent namely 2-(3,5-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol estimated through HPTLC analysis of the extract. Thus, the study exhibited the protective effect of ethanolic extract of Randia dumetorum fruits against doxorubicin induced cardiotoxicity.

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“…The Indian government has started promoting its cultivation due to its high economic perspective [15,16]. This plant is also used as a culinary food in India [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Varieties and Spacing on Vegetative Growth and Root Yield of Safed Musli (Chlorophytum borivilianum)

Ram¹,

Saini²

2022

IJPSS

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The experiment entitled “Effect of varieties and spacing on vegetative growth and root yield of safed musli (Chlorophytum borivilianum)” was carried out to find out the suitable variety with optimum spacing 2018-19 and 2019-20 which was designed in factorial RBD with two varieties and three spacing levels. The trials were sown in two years i.e. on 02-07-2018 and 31-05-2019. The present investigation has been carried out at the main experiment station, Department of Horticulture at Medicinal and Aromatic Plant, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya, Uttar Pradesh, India. The data has been recorded in the following parameters, like leaf length, leaf width, number of tillers/hill, length and diameter of fingers, number of fingers per plant, fresh root yield, and dry root yield. It is effective against male sexual disorders such as erectile dysfunction, premature ejaculation, and infertility and is used as a health tonic.

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A Review on Woodfordia fruticosa Kurz (Dhatki): Ayurvedic, Folk and Modern Uses

Cited by 7 publications

References 23 publications

Antiatherosclerotic Activity of Methanolic Extract of Woodfordia fructicosa Flowers

Antiatherosclerotic Activity of Methanolic Extract of Woodfordia fructicosa Flowers

Cardioprotective Actvity of Randia Dumetorum against Doxorubicin Induced Cardotoxicity

Effect of Varieties and Spacing on Vegetative Growth and Root Yield of Safed Musli (Chlorophytum borivilianum)

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