Cardioprotective Actvity of Randia Dumetorum against Doxorubicin Induced Cardotoxicity

Abstract

In the present investigation the cardioprotective activity of ethanolic extract of Randia dumetorum fruits at the doses of 100, 200 and 400 mg/kg was investigated against doxorubicin induced cardiotoxicity model. In high fat diet induced atherosclerosis several heamodynamic parameters such as systolic and diastolic blood pressure, serum parameters such as lactate dehydrogenase (LDH), tissue parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), and malonaldehyde (MDA) were determined and found to be significantly altered in induction control group treated with doxorubicin. The histopathological studies of cardiac tissue were also performed wherein doxorubicin showed toxic effects on tissue. Ethanolic extract of Randia dumetorum fruits showed protection against doxorubicin induced cardiotoxicity by normalizing the altered parameters and producing ameliorating effects against doxorubicin induced cardiac damage. The multistep putative action of ethanolic extract of Randia dumetorum fruits may be attributed to the prominent phytoconstituent namely 2-(3,5-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol estimated through HPTLC analysis of the extract. Thus, the study exhibited the protective effect of ethanolic extract of Randia dumetorum fruits against doxorubicin induced cardiotoxicity.