In the present investigation the cardioprotective activity of ethanolic extract of Randia dumetorum fruits at the doses of 100, 200 and 400 mg/kg was investigated against doxorubicin induced cardiotoxicity model. In high fat diet induced atherosclerosis several heamodynamic parameters such as systolic and diastolic blood pressure, serum parameters such as lactate dehydrogenase (LDH), tissue parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), and malonaldehyde (MDA) were determined and found to be significantly altered in induction control group treated with doxorubicin. The histopathological studies of cardiac tissue were also performed wherein doxorubicin showed toxic effects on tissue. Ethanolic extract of Randia dumetorum fruits showed protection against doxorubicin induced cardiotoxicity by normalizing the altered parameters and producing ameliorating effects against doxorubicin induced cardiac damage. The multistep putative action of ethanolic extract of Randia dumetorum fruits may be attributed to the prominent phytoconstituent namely 2-(3,5-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol estimated through HPTLC analysis of the extract. Thus, the study exhibited the protective effect of ethanolic extract of Randia dumetorum fruits against doxorubicin induced cardiotoxicity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.