A review on the effects of ionizing radiation on blood and blood components

Effects of ionizing radiation on extracellular matrix

“…For elastin, the effect of radiation was to weaken the tissue, again presumably due to chain breakage [13]. This process would obviously weaken tissues such as ligaments which are almost entirely elastin.…”

“…This process would obviously weaken tissues such as ligaments which are almost entirely elastin. In more complex structures such as blood vessels the effects of radiation could be more complex [13]. In the normal tissue, elastin provides an initial compliance before higher loads are transferred to a collagenous network.…”

Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells

“…However, Brugnara et al [11] showed that the increase in plasma potassium and sodium concentrations may be not due to damage to the pumps, but may be due to hemolysis of the RBCs' membranes that results in increasing the membrane permeability. However, Jacobs [12] showed that irradiation of RBCs at very high doses, e.g., 200 Gy, has no an evident impact on the cell morphology.…”

Studies of the antioxidant and antihemolytic activity of quinoline derivatives in a model of oxidative damage to erythrocyte membranes

“…Biological membranes are known to be among the critical radiosensitive target structures, radiation damage to which may be responsible for lethal outcomes, as high levels of polyunsaturated fatty acids among the phospholipid components of biological membranes result in high sensitivity to oxidative reactions and massive accumulation of excess levels of cytotoxic oxidation products, which stimulate the development of oxidative cell degradation [24,25]. It can be suggested that substances able to suppress peroxidation chain reactions, neutralizing active forms of oxygen and thus protecting cell membranes from the damaging actions of free radicals, may have radioprotective properties.…”