A Review on Plant Flavonoids as Potential Anticancer Agents

Kapoor, Bhupinder; Gulati, Monica; Gupta, Reena; Singh, Sachin Kumar; Gupta, Manohar Lal; Nabi, Arshid; Chawla, Pooja

doi:10.2174/1385272824999201126214150

Cited by 15 publications

(12 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plant flavonoids are polyphenolic chemicals obtained mostly from vegetables, nuts, seeds, and fruits that are important components of green tea and cocoa-based beverages. Flavonoids have been proven to show anticancer effects through a variety of mechanisms, including anti-oxidation, inactivation of carcinogen, apoptosis induction, angiogenesis inhibition, and alterations of multidrug resistance (Goya-Jorge et al 2021 ; Kapoor et al 2021 ). Consumption of flavonoids has been demonstrated to have cardiovascular and antithrombotic therapeutic benefits due to antiplatelet action.…”

Section: Flavonoidsmentioning

confidence: 99%

Flavonoid mediated selective cross-talk between plants and beneficial soil microbiome

et al. 2022

View full text Add to dashboard Cite

Plants generate a wide variety of organic components during their different growth phases. The majority of those compounds have been classified as primary and secondary metabolites. Secondary metabolites are essential in plants’ adaptation to new changing environments and in managing several biotic and abiotic stress. It also invests some of its photosynthesized carbon as secondary metabolites to establish a mutual relationship with soil microorganisms in that specific niche. As soil harbors both pathogenic and beneficial microorganisms, it is essential to identify some specific metabolites that can discriminate beneficial and pathogenic ones. Thus, a detailed understanding of metabolite’s architectures that interact with beneficial microorganisms could open a new horizon of ecology and agricultural research. Flavonoids are used as classic examples of secondary metabolites in this study to demonstrate recent developments in understanding and realizing how these valuable metabolites can be controlled at different levels. Most of the research was focused on plant flavonoids, which shield the host plant against competitors or predators, as well as having other ecological implications. Thus, in the present review, our goal is to cover a wide range of functional and signalling activities of secondary metabolites especially, flavonoids mediated selective cross-talk between plant and its beneficial soil microbiome. Here, we have summarized recent advances in understanding the interactions between plant species and their rhizosphere microbiomes through root exudates (flavonoids), with a focus on how these exudates facilitate rhizospheric associations. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-022-09806-3.

show abstract

Section: Flavonoidsmentioning

confidence: 99%

Flavonoid mediated selective cross-talk between plants and beneficial soil microbiome

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These results were due to the extract's action on the surface of nanoparticles. E. retusa has been shown to contain anticancer metabolites, such as coumarines, flavonoids, ellagitannins, and phenolic acids [30][31][32][33]. An immunoblotting experiment using caspase-8 and COX-2 was used to investigate the mechanism of action.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Cytotoxic Activity of Zinc Oxide Nanoparticles Mediated by Euphorbia Retusa

et al. 2022

View full text Add to dashboard Cite

Background: Cancer is a dangerous threat that creates extremely high rates of death and morbidity in various regions of the world. Finding suitable therapeutics to improve cancer therapy while avoiding side effects is critical. The most appropriate innovative therapeutics, which combine natural ingredients and nanomaterials, can improve the biological activity of cancer chemotherapeutics. Methods: Phenolic profiling using high-resolution mass spectrometry and the synthesis of zinc oxide nanoparticles was achieved through the reaction of zinc acetate with Euphorbia retusa extract. The characterization of ZnONPs was performed by UV, IR, Zeta potential, XRD, SEM, and TEM. The cytotoxic activity of the ZnONPs was evaluated using a SRB assay against lung, liver, and breast cancer cell lines. Moreover, the mechanism of cytotoxic activity was evaluated in the form of caspase-8 promoters and anti-inflammatory mechanisms using the Western blot method. Results: The high-resolution LC/MS/MS of the E. retusa led to the identification of 22 compounds in the plant for the first time. The Er-ZnONPs had hexagonal shapes, were approximately 100 nm in size, and consisted of aggregated particles of about 10 nm. The E. retusa ZnONPs exhibited cytotoxic activity against HA-549 (IC50 = 22.3 µg/mL), HepG2 (IC50 = 25.6), Huh-7 (IC50 = 25.7), MCF-7 (IC50 = 37.7), and MDA-MB-231 (IC50 = 37). Conclusions: E. retusa are rich in phenolics that are capable of synthesizing ZnONPs, which possess cytotoxic activity, via caspase-8 promotion and anti-inflammatory mechanisms.

show abstract

“…They may interfere in the cell growth regulating pathways, energy metabolism, apoptosis, cell division, transcription, repair genes, inflammation, stress response, and may act on tumor formation (Havsteen, 2002). Thus, flavonoids are promising molecules in the treatment of tumors (Kapoor et al, 2021).…”

Section: Total Phenolic Compounds and Total Flavonoidsmentioning

confidence: 99%

Modulation of hemostasis by inhibiting enzymes with the extract of Averrhoa carambola leaves

Oliveira¹,

César²,

Trento³

et al. 2021

J. Biotechnol. Biodivers.

View full text Add to dashboard Cite

Herbal medicines represent an advantageous alternative for the prevention and treatment of several diseases when compared to allopathic medicines. Averrhoa carambola (Oxalidaceae) is a plant rich in phenolic compounds and popularly known for its medicinal properties such as anti-inflammatory, antioxidant, and hypoglycemic. Different enzymes of the human organism participate in physiological processes which involve hemostasis, inflammation, and formation of new tissue. These enzymes are highlighted as pharmaceutical targets for the treatment of numerous pathologies. The present work evaluated the aqueous and ethanolic extracts from A. carambola leaves on phospholipase, hemolytic, caseinolytic, thrombolytic, coagulant, and fibrinogenolytic activities induced by phospholipases A2 and proteases. Phenolic compounds and total flavonoids were quantified in the aqueous and ethanolic extracts of the leaves of Averrhoa carambola. These extracts were evaluated, in vitro, on phospholipase, proteolytic, hemolytic, thrombolytic and fibrinogenolytic activities induced by snake venoms. The results confirm the pharmacological potential of A. carambola since the extracts were able to modulate all evaluated activities related to hemostasis through inhibitions or potentiation of the enzymatic activities (phospholipases A2 and proteases). The constituents of A. carambola may act interfering in processes such as coagulation, thrombus dissolution, and fibrinogenolysis.

show abstract

A Review on Plant Flavonoids as Potential Anticancer Agents

Cited by 15 publications

References 92 publications

Flavonoid mediated selective cross-talk between plants and beneficial soil microbiome

Flavonoid mediated selective cross-talk between plants and beneficial soil microbiome

Cytotoxic Activity of Zinc Oxide Nanoparticles Mediated by Euphorbia Retusa

Modulation of hemostasis by inhibiting enzymes with the extract of Averrhoa carambola leaves

Contact Info

Product

Resources

About