A review on chitosan centred scaffolds and their applications in tissue engineering

Ahmed, Shakeel; Annu, .; Ali, Akbar; Sheikh, Javed

doi:10.1016/j.ijbiomac.2018.04.176

Cited by 197 publications

(75 citation statements)

References 124 publications

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“…The cell culture experiments showed the better cytocompatibility of composite films as compared to native chitosan films. Such developed composites had potential applications in tissue engineering …”

Section: Phb Based Biocompositesmentioning

confidence: 99%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio‐based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco‐friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.

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Section: Phb Based Biocompositesmentioning

confidence: 99%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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“…Chitosan is a binary linear (amino)polysaccharide copolymer derived from chitin by deacetylation. As a nontoxic, biocompatible and biodegradable (poly)cationic polymer with film forming and gelling properties, chitosan has become one of the most intensively studied biopolymers in the field of drug delivery and tissue engineering . Chitosan films exhibit mucoadhesivity, satisfactory vapor and oxygen barrier properties which make them particularly interesting for wound healing and topical drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass

Čalija

Milić

Milašinović

et al. 2019

J of Applied Polymer Sci

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This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48406.

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“…Polysaccharides are attractive materials that can be examined in composite systems for developing hydrogels because of their easy modification, abundance, and good biocompatibility in many instances . Chitosan (CS), a cationic natural polymer derived from chitin, has been widely used in various fields, including drug delivery and biotechnology . This polymer possesses great biocompatibility, biodegradability, antibacterial properties, hemostatic activity, and low mechanical properties .…”

Section: Introductionmentioning

confidence: 99%

Effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol)–chitosan blend films at different weight ratios

Jahanabadi

Sheikh²,

Mahdavi

et al. 2019

J of Applied Polymer Sci

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The aim of this study was to examine the effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol) (PVA)–chitosan (CS) blend films. Solution‐cast films containing various ratios of polymers were exposed to irradiation doses of 26, 39, and 52 kGy at room temperature and then annealed at 100 °C. The results show that at all doses, with an increase in the weight ratio of CS, the gel content of the samples decreased, and the water absorption of the samples increased. The irradiation dose ranged from 26 to 39 kGy; this led to an increased gel content and a decreased degree of swelling in the samples. However, at 52 kGy, an increase in the amount of swelling was observed. X‐ray diffraction analysis and scanning electronic microscopy images of the samples revealed that the increase in the irradiation dose reduced the crystallinity and increased the surface heterogeneity, respectively. The tensile strength of the blends decreased with decreasing PVA–CS weight ratio. This property of the samples increased with dose from 26 to 39 kGy and decreased at 52 kGy. The elongation at break of the samples decreased with both an increase in the irradiation dose and a decrease in the CS content. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47820.

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A review on chitosan centred scaffolds and their applications in tissue engineering

Cited by 197 publications

References 124 publications

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass

Effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol)–chitosan blend films at different weight ratios

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