A review of the phytochemistry and pharmacological activities of Magnoliae officinalis cortex

Luo, Haidong; Wu, Hongwei; Yu, Xiankuo; Zhang, Xiao; Lü, Yanjun; Fan, Jianwei; Tang, Liying; Wang, Zhuju

doi:10.1016/j.jep.2019.02.041

Cited by 81 publications

(60 citation statements)

References 104 publications

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“…According to other studies, safety and toxicity of magnolia bark do not differ notably but may reflect insufficiencies of these toxicity studies. Therefore, currently, studies of the mechanisms of toxicity of magnolia bark are insufficient (Luo et al, 2019). However, in the context of COVID-19, magnolol has been identified as a potential enhancer of ACE2 expression (ANSES, 2020).…”

Section: Magnolia Officinalis Rehder and Eh Wilson -Magnoliaceae (Bark)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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Section: Magnolia Officinalis Rehder and Eh Wilson -Magnoliaceae (Bark)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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“…O grupo dos alcaloides também apresentaram resultados positivos para todos os extratos etanólicos avaliados, em especial para os extratos de rizoma, folha e flor de S. elatior. Compostos alcaloides apresentam atividades broncodilatadora (Oghale & Idu, 2016), antitumoral e abirritação (Luo et al, 2019).…”

Section: Na Figura 3 Pranchas (A E B) Estão Apresentadas Asunclassified

Análise morfológica foliar por diafanização, morfometria dos órgãos vegetativos, composição fitoquímica dos extratos etanólicos e atividade hemolítica em Sinningia elatior (Kunth) Chautems (Gesneriaceae)

Filho

Castro

2020

MSJ

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A presença de Sinningia elatior (Kunth) Chautems (Gesneriaceae) é citada pela primeira vez na flora da região Centro-Oeste em Goiás, Brasil. Foram realizadas coletas de plantas inteiras de S. elatior em área de mata de galeria. O material foi levado para o laboratório onde foi separado por órgão vegetativo (rizoma, galho, folha e flor). Foram realizadas análises de diafanização foliar, morfometria dos órgãos vegetais, o pólen foi avaliado por modelagem matemática em 3D e para os extratos, análises físico-química, fitoquímica e hemolítica. As plantas de S. elatior apresentaram em todos os órgãos superiores a presença tricomas tectores, com inervação até 5ª ordem, os estômatos são do tipo anisocíticos, para a fitoquímica, todas as classes de compostos foram positivas, exceto para resinas. Os extratos etanólicos de S. elatior demonstraram importante ação hemolítica no tempo máximo de 5 minutos. Os resultados obtidos neste estudo para S. elatior apresentaram importantes dados morfológicos, morfométricos para os órgãos aéreo e subterrâneo, e importantes classes de compostos fitoquímicos com importância nas indústrias agrícola, farmacêutica e alimentícia.

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“…The main PhGs are reported from the families Acanthaceae, Asteraceae, Berberidaceae, Gesneriaceae, Lamiaceae, Loganiaceae, Magnoliaceae, Oleaceae, Orobanchaceae, Plantaginaceae, Portulacaceae, Rosaceae, Scrophulariaceae, and Verbenaceae 4 . For example, a total of 69, 51, 21, and 16 PhGs have been isolated from Cistanche herba , 5 Forsythiae fructus , 6 Magnoliae officinalis , 7 and Houttuynia cordata , 8 respectively. Verbascoside (also known as acteoside), one of the representative PhGs, is widely distributed in the family Lamiaceae, Plantaginaceae, Scrophulariaceae, and Orobanchaceae 9 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of phenylethanoid glycosides: A systematic review

Georgiev

Cao

et al. 2020

Medicinal Research Reviews

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Phenylethanoid glycosides (PhGs) are generally watersoluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest

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A review of the phytochemistry and pharmacological activities of Magnoliae officinalis cortex

Cited by 81 publications

References 104 publications

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Análise morfológica foliar por diafanização, morfometria dos órgãos vegetativos, composição fitoquímica dos extratos etanólicos e atividade hemolítica em Sinningia elatior (Kunth) Chautems (Gesneriaceae)

Therapeutic potential of phenylethanoid glycosides: A systematic review

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