A Review of The Anti-diabetic Activity of Andrographis paniculata (Burm. f.) Nees based in-vivo Study

Abstract

Diabetes mellitus (DM) is ricing nowadays. DM is a metabolic deasease characterized by increasing of glucose blood level for prolonged time. Patient with DM must take medicine for lowering glucose levels in whole life. Synthetic anti-diabetic agent is commonly used and significantly able to maintain the glucose blood levels. However, many side effects will occur during the treatment. Further, people is trying to find an alternative medicine for DM treatment. This paper will discuss about an alternative medicine for anti-diabetic agent that is called <em>Andrographis paniculata</em> (Burm. f.) Nees based <em>in-vivo</em> study. Search data obtained from PubMed, PMC (PubMed Central), International Food and Research Journal, and Google search engine. Inclution and exclution criteria were used for selection of journals. Inclution criteria were taken is i<em>n-vivo </em>study of <em>Andrographis paniculata</em> as anti-diabetic, published in 2000-2014, and free full text journal or PubReader (full text journal in PubMed Central) in English or Indonesian language. Base on reviewed journals that was conducted, anti-diabetic agent of <em>Andrographis paniculata </em>was found in extract, in fractional coumpund (i.e. andrographolide or its analogue AL-1: andrographolide-lipoic acid), and in combination with synthetic drug or other herbal. Therefore, <em>Andrographis paniculata</em> is potentially developed as an alternative anti-diabetic agent.

Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes

“…f.) Wall. ex Nees (AP) is described as one among the prioritized medicinal plants and this herb is being used mainly for jamu pahitan, whose use is a part and parcel of Indonesian culture recognized internationally (Komalasari and Harimurti, 2015;Lanawati et al, 2012;Limyati and Juniar, 1998). The antidiabetic effects of A. paniculata have been investigated by number of researchers from in silico studies to human evidence (Kooti et al, 2016;Niranjan et al, 2010;Nizmawardini et al, 2013;Xu et al, 2007Xu et al, , 2010.…”

Inhibition of α-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics

“…Andrographolide with m/z 351 (Rafi et al 2021 . This compound is the most dominant in the diterpene lactone group and has a high abundance, especially in the leaves (Komalasari and Harimurti 2015). Andrographolide is also a compound that plays an important role in biological activity as an antidiabetic (Nugroho et al 2012).…”

UJI INTERAKSI METFORMIN DAN GLIBENKLAMID DENGAN JAMU YANG MENGANDUNG Smallanthus sonchifolius DAN KOMBINASI Andrographis paniculata (Burm. F), Boesenbergia pandurata Roxb, Phyllanthus niruri L, Syzigii polyanthi Wight PADA PENURUNAN KADAR GLUKOSA DARAH TI

“…Penurunan aktivitas antidiabetes dalam menurunkan kadar glukosa darah antara kombinasi metformin dan glibenklamid dengan jamu diprediksi akibat munculnya efek interaksi obat-obat herbal pada fase farmakokinetika (absorbsi, distribusi, metabolism, dan eliminasi). Kandungan senyawa yang terdapat dalam jamu A dan B diprediksi mampu menghambat absorbsi metformin sehingga efek hipoglikemik menjadi menurun (30). Sedangkan pada kombinasi dengan glibenklamid diprediksi melibatkan aktivitas dari enzim pemetabolisme sitokrom P450 terutama CYP3A4 dan CYP2C9 yang merupakan enzim pemetabolisme utama dari glibenklamid (31).…”