Daun Kelor (Moringa oleifera) merupakan salah satu tanaman yang mengandung senyawa fenol seperti alkaloid tannin saponin dan flavonoid yang berkhasiat sebagai antioksidan dan anti aging. Penelitian ini bertujuan untuk membuktikan aktivitas antioksidan dan anti aging daun kelor serta membuat Formulasi Body Butter dari ekstrak daun kelor. Proses ekstraksi daun kelor metode Maserasi dengan pelarut etanol 70 % perbandingan 1:10 kemudian dilakukan uji aktivitas antioksidan dengan metode beta caroten bleaching (BCB) dan anti aging selanjutnya dilakukan formulasi body butter dengan bahan aktif ekstrak daun kelor 0,5 %. Hasil penetapan kadar Fenolik total dan Flavonoid total ekstrak daun kelor menunjukkan kadar yang dihasilkan yaitu sebesar 10,45 mgGAE/g ekstrak untuk fenolik total dan 5,53 % untuk Flavonoid Total. Hasil penelitian menunjukkan bahwa ekstrak daun kelor memiliki aktivitas penghambatan proses pemucatan beta karoten (inhibitor BCB) dan inhibitor enzim kolagenase dengan persentase penghambatan sebesar 47 %. Body Butter ekstrak daun kelor mempunyai potensi sebagai antiaging melalui mekanisme anti oksidan dan inhibitor kolagenase. Body butter ekstrak daun kelor mempunyai penampakan organoleptis yang sudah baik dan menarik. Namun sifat fisik dari moringa body butter masih memerlukan optimasi agar lebih baik dan memenuhi standar yang telah ditetapkan.
Co-administered medicinal herbs can modify a drug’s pharmacokinetics (PK), effectiveness, and toxicity. Andrographis paniculata (Burm. f.) ethanolic extract (APE) and andrographolide (AND) (a potent CYP2C9 inducer/inhibitor) can alter the pharmacokinetic parameters of glipizide (GLZ). This study aimed to determine the potential pharmacokinetics of herb–drug interactions between GLZ and APE/AND in the plasma of normal and diabetic rats using the HPLC bioanalysis method. The glipizide bioanalytical method established with RP-HPLC/UV instrument was validated following the EMA guidelines. GLZ was administered alone and in combination with APE or AND to normal and diabetic rats. The GLZ pharmacokinetic parameters were estimated according to the correlation between concentration and sampling time using the PK solver program. A simple and rapid GLZ bioanalysis technique with a lower limit of quantitation of 25 ng/mL was developed and presented the following parameters: accuracy (error ≤ 15%), precision (CV ≤ 15%), selectivity, stability, and linearity (R2 = 0.998) at concentrations ranging 25–1500 ng/mL. APE administration significantly improved the Cmax and AUC0–t/AUC0–∞ GLZ values in normal and diabetic rats (p < 0.05). AND significantly reduced the bioavailability of GLZ in diabetic rats with small values of T 1/2, Cmax, and AUC0–t/AUC0–∞ (p < 0.05). This combination can be considered in administering medications because it can influence the pharmacological effects of GLZ.
Introduction: Herb–drug interactions (HDIs) in pharmacokinetics and pharmacodynamics can occur when natural compounds are used in combination with drugs. This study aimed to review the potential interaction of Andrographis paniculata (Burm. f.) extract (APE) and its primary compound andrographolide (AND) with several drugs exhibiting various pharmacological activities.Methods: In this systematic review, articles were collected from international databases such as PubMed, Science Direct, Springer Link, and Scopus until August 2021. The following keywords were used: Andrographis paniculata, andrographolide, HDI, drug interaction, pharmacokinetics, and pharmacology. This review was written in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), SYRCLE’s risk of bias (RoB) tool for animal intervention studies, and Cochrane RoB 2 tool to analyze the RoB for qualitative assessment.Results: Twelve articles were included in accordance with the inclusion and exclusion criteria of this study. Five studies explored the potential of HDIs for combining APE with drugs and AND with theophylline, etoricoxib, nabumetone, naproxen, and tolbutamide. Five studies focused on AND in combination with aminophylline and doxofylline, meloxicam, glyburide, glimepiride, metformin, and warfarin. Two studies tested the combination of APE with gliclazide and midazolam. The HDI mechanism involving the inhibition or induction of cytochrome P450 enzyme expression was dominant in influencing the drug’s pharmacokinetic profile. Pharmacological studies on the combination of several drugs, particularly anti-inflammatory and antidiabetic drugs, showed a synergistic activity.Conclusion: APE and AND have potential pharmacokinetic and pharmacodynamic HDIs with various drugs. This study can be used as a therapeutic consideration in clinical aspects related to the possibility of HDIs of A. paniculata (Burm. f.).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.