Abstract:The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater a… Show more
“…Microspheres can reduce side effects and immune rejection, produce efficiently, increase duration and stability of the structure, and are affordable, injectable, and sterilizable. 10 They are numerously used individually in bone reconstruction, 11 or in three-dimensional scaffolds 12 ; moreover, their ability to encapsulate drugs, genes, hormone, etc., increases their effectiveness. Despite the introduction of a variety of techniques for fabrication of these biocompatible vehicles such as spraying, 13 phase separation, 14 emulsion-based methods, 15,16 suspension or dispersion polymerization, 17 extrusion methods, 18 etc., single emulsion technique have been utilized copiously for the fabrication of gelatin microspheres or other carbohydrate proteins because of their dissolvability in aqueous medium.…”
“…Microspheres can reduce side effects and immune rejection, produce efficiently, increase duration and stability of the structure, and are affordable, injectable, and sterilizable. 10 They are numerously used individually in bone reconstruction, 11 or in three-dimensional scaffolds 12 ; moreover, their ability to encapsulate drugs, genes, hormone, etc., increases their effectiveness. Despite the introduction of a variety of techniques for fabrication of these biocompatible vehicles such as spraying, 13 phase separation, 14 emulsion-based methods, 15,16 suspension or dispersion polymerization, 17 extrusion methods, 18 etc., single emulsion technique have been utilized copiously for the fabrication of gelatin microspheres or other carbohydrate proteins because of their dissolvability in aqueous medium.…”
“…Biopesticide synthesis requires surfactants to coat its surface (Mout et al, 2012). Nanoparticles tend to agglomerate; thus, stabilizers play an important role in the synthesis of nanoparticles (Kadam et al, 2015). The choice of stabilizing agent for nanoparticles is very important because stabilizers often affect various properties of nanoparticles, including their size, shape, and interaction with solvents (Ajitha et al, 2016).…”
Section: Effect Of Tween 80 and Peg 400mentioning
confidence: 99%
“…The choice of stabilizing agent for nanoparticles is very important because stabilizers often affect various properties of nanoparticles, including their size, shape, and interaction with solvents (Ajitha et al, 2016). The use of Tween and PEG surfactants improves the solubility of solutes in the dispersion medium by increasing the flexibility of the surface layer of the particles (Kadam et al, 2015). The stabilizers or surfactants used in this study were Tween 80 and PEG 400 because they are non-toxic and function as emulsifying agents, solvents, and particle-size stabilizers.…”
Essential oils are environment-friendly natural ingredients that can be used as biopesticides. Biopesticide formulation using nutmeg seed oil (Myristica fragrans Houtt) and its application as an inhibitor of lichen growth on rocks. This study aimed to synthesize biopesticides and determine their inhibitory activity on lichen growth on rocks. The biopesticide was synthesized by adding AgNO3 powder directly to the nutmeg seed oil, Tween 80 surfactant, and PEG 400 co-surfactant. The synthesized biopesticide had a dark brown color, indicating that the reduction process was successful, as shown by the formation of absorption at a wavelength of 437 nm. The results of the PSA and SEM-EDX analyses showed that the biopesticide had a particle size of 454.8 nm and was spherical in shape with Ag, C and O contents of 59.07%, 28.94% and 11.99% respectively. The addition of Tween 80 and PEG 400 surfactants resulted in particle sizes of 235 nm and 406.2 nm respectively, and a round and non-uniform shape. Tween 80 affects the synthesis of nutmeg oil biopesticide, that is, it is more stable. The synthetic biopesticide is effective as an anti-lichen on stone surfaces.
“…Apontam Bonifácio et al (2014) que essas estratégias oferecidas pela nanotecnologia têm outras vantagens que podem ser exploradas em outras áreas como a conservação de drogas da fotodegradação e termodegradação, adição de outras substâncias úteis na formulação de medicamentos, aumento da seletividade e eficácia, redução de efeitos secundários e liberação controlada. Kadam (2015) mostra que estruturas como nanoplex associadas com os medicamentos antineoplásicos oferecerem vantagens como aumento da taxa de dissolução e solubilidade, reduzindo assim a dose de medicamentos. Em outras aplicações como a terapia fototérmica mediada por nanomateriais (PTT) com partículas de ouro, são oferecidos recursos para tratar tumores que por cirurgias seriam complicados em regiões vitais, assim evitando a resistência de células cancerígenas (WANG, 2015).…”
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