“…The first migraine GWAS established association between 2 genes, MTDH and PGCP , and the risk for migraine . This finding was confirmed in 2 replication studies, whereas other studies showed lack of association . The putative associations of migraine with diverse SNPs have been refined in some studies .…”
Section: Clinical Epidemiological Biochemical Experimental and Phmentioning
confidence: 62%
“…2 This finding was confirmed in 2 replication studies, 3,4 whereas other studies showed lack of association. 5,6 The putative associations of migraine with diverse SNPs have been refined in some studies. [7][8][9] Ligthart et al 3 reported association of one SNP in NGFR gene and the risk for migraine, but they could not replicate this finding in 3 cohorts.…”
Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.
“…The first migraine GWAS established association between 2 genes, MTDH and PGCP , and the risk for migraine . This finding was confirmed in 2 replication studies, whereas other studies showed lack of association . The putative associations of migraine with diverse SNPs have been refined in some studies .…”
Section: Clinical Epidemiological Biochemical Experimental and Phmentioning
confidence: 62%
“…2 This finding was confirmed in 2 replication studies, 3,4 whereas other studies showed lack of association. 5,6 The putative associations of migraine with diverse SNPs have been refined in some studies. [7][8][9] Ligthart et al 3 reported association of one SNP in NGFR gene and the risk for migraine, but they could not replicate this finding in 3 cohorts.…”
Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.
“…The first GWAS of migraine, which was published by the International Headache Genetics Consortium in 2010, identified the minor allele of rs1835740 at 8q22.1 to confer migraine susceptibility (OR = 1.23, 95% CI 1.15‐1.32, P = 5.389 *10‐9) . But subsequent replication studies of this GWAS performed in a Spanish cohort and in the WGHS cohort failed to replicate the association between rs1835740 and migraine . The second GWAS was a meta‐analysis of GWAS on migraine performed by the Dutch–Icelandic migraine genetics consortium.…”
Our study confirmed the association of PRDM16 to migraine susceptibility in the Chinese Han population. The results also indicated that replication studies of previous GWAS findings across populations is of importance to validate these associations and to gain a better understanding of migraine susceptibility of potential genetic heterogeneity between populations. Further work is necessary to understand the functional mechanisms underlying these variants identified by GWAS.
“…Our results also identified the role of other genome‐wide associated variants such as LRP1 rs11172113 and PRDM16 rs2651899 in high order genetic interactions in migraine. Some groups have carried out replication studies of genome‐wide associated variants and have reported both positive and negative results . The present study suggests that, although genome‐wide variants might not show very strong significance individually, they definitely act as modifiers and influence susceptibility to migraine in combination with other risk variants.…”
The present study suggests interactions amongst hormonal, inflammatory and genome-wide associated variants but not with neurotransmitter pathway variants in migraine susceptibility.
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