<i>Diamine Oxidase</i> <scp>rs</scp>10156191 and <scp>rs</scp>2052129 Variants Are Associated With the Risk for Migraine

García‐Martín, Elena; Martı́nez, Carmen; Serrador, Mercedes; Alonso‐Navarro, Hortensia; Ayuso, Pedro; Navacerrada, Francisco; Agúndez, José A. G.; Jiménez‐Jiménez, Félix Javier

doi:10.1111/head.12493

Cited by 52 publications

(62 citation statements)

References 45 publications

(92 reference statements)

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“…Previous works suggest that imbalances in histamine degradation capacity may associate with the development of migraine and atopic dermatitis [3, 4], but little is known on the role of DAO in CSU. Taken together, our data suggest that DAO activity could be a cofactor in the development of CSU clinical manifestations and that DAO supplementation could contribute to a better disease control.…”

Section: Discussionmentioning

confidence: 99%

“…Histamine lies downstream the pathogenic cascade that leads to the development of itch and wheals in CSU as well as in most immediate-type hypersensitivity reactions, since it prompts vasodilation and increased vascular permeability [2]. Furthermore, histamine-related events have been implicated in the pathogenesis of other diseases such as atopic dermatitis and migraine [3]. Systemic and local levels of histamine are influenced by mast cell release, gastrointestinal absorption and catabolic efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Yacoub¹,

Ramirez²,

Berti³

et al. 2018

Int Arch Allergy Immunol

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Introduction: Diamine oxidase (DAO) catabolizes and inactivates histamine, a key player in a wide range of invalidating conditions, such as migraine and chronic spontaneous urticaria (CSU). The highest expression of DAO occurs in the gastrointestinal tract, possibly to control the burden of histamine intake from food. Methods: Here, we tested the hypothesis that a 30-day oral supplementation with DAO (1 capsule b.i.d., 15 min before a meal) could reduce the severity of CSU as estimated by the 7-Day Urticaria Activity Score (UAS-7). The study was designed as a double-blind, placebo-controlled, crossover investigation of 22 patients with CSU incompletely controlled by first-line antihistamine therapy. Results: Twenty patients completed the study. Supplemental therapy with DAO caused a 3.8 ± 1.2 point mean ± SEM UAS-7 score reduction in patients with low serum DAO levels at time 0 (p = 0.041 compared to placebo). The degree of UAS-7 improvement was inversely correlated with the levels of basal DAO (p = 0.019). Patients receiving DAO supplementation were able to slightly reduce their daily antihistamine dose (p = 0.049). Conclusion: These data suggest that DAO may be involved in the pathogenic cascade of CSU and that DAO supplementation could be effective for symptom relief in patients with low DAO levels in serum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Yacoub¹,

Ramirez²,

Berti³

et al. 2018

Int Arch Allergy Immunol

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“…Recruitment of patients was done in the general neurological clinics of 3 University Hospitals during the period between September 2006 and August 2007 (the onset of migraine attacks was under age 15 years in 113 patients, positive family history for migraine was reported by 147 patients, and 98 of them had MWA). Most of these patients have participated previously in other genetic association studies reported by our group …”

Section: Methodsmentioning

confidence: 99%

“…Most of these patients have participated previously in other genetic association studies reported by our group. 3,[53][54][55][56][57][58] Control individuals were healthy Caucasian Spanish subjects recruited from professors or students from the University of Extremadura, who did not suffer from migraine or other headache types, and have not familial history of migraine. They were interviewed by three physicians (Drs.…”

Section: Methodsmentioning

confidence: 99%

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Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine

et al. 2017

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Vitamin D receptor and binding protein genes variants in patients with migraine

García‐Martín,

Navarro‐Muñoz,

Ayuso

et al. 2023

Ann Clin Transl Neurol

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Background/ObjectivesSeveral studies have shown a relationship between vitamin D and migraine, including the association between decreased serum 25‐hydroxyvitamin D in patients with migraine and the positive effects of vitamin D supplementations in the therapy of this disease. Two single‐nucleotide variants (SNVs) vitamin D receptor (VDR) gene, VDR rs2228570, and VDR rs731236 have shown an association with migraine risk in a previous case–control association study, while an exome sequencing study identified a rare variant in GC vitamin D binding protein gene. This study aims to look for the association between several common variants in these two genes and the risk for migraine.MethodsWe genotyped 290 patients diagnosed with migraine and 300 age‐matched controls using specific TaqMan assays for VDR rs2228570, VDR rs731236, VDR rs7975232, VDR rs739837, VDR rs78783628, GC rs7041, and GC rs4588 SNVs.ResultsWe did not find an association between these SNVs and the risk for migraine. None of these SNVs were related to the positivity of a family history of migraine or with the presence of aura. The VDR rs731236A allele showed a significant association with the triggering of migraine attacks by ethanol (Pc = 0.007).ConclusionsIn summary, the results of the current study suggest a lack of association between common SNVs in the VDR and GC gene and the risk of developing migraine. The possible relationship between VDR rs731236 and the triggering of migraine episodes with ethanol deserves future studies.

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Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine

Abstract: Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.

Cited by 52 publications

References 45 publications

Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine

Vitamin D receptor and binding protein genes variants in patients with migraine

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